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低血糖症如何影响糖尿病患者的日常生活,以及他们是否能够充分应对这些情况?

How do hypoglycaemias affect the everyday life of people with diabetes and are they able to treat them adequately?

作者信息

Müller Nicolle, Kellner Christiane, Schmidt Sebastian, Kuniß Nadine, Wolf Gunter, Kloos Christof

机构信息

Department for Internal Medicine III, Jena University Hospital, Jena, Germany.

Outpatient Healthcare Center MED:ON MVZ, Erfurt, Germany.

出版信息

Diabet Med. 2025 Oct;42(10):e70121. doi: 10.1111/dme.70121. Epub 2025 Aug 16.

Abstract

AIMS

To investigate whether people with type 1 and type 2 diabetes respond adequately to hypoglycaemia symptoms after participating in a treatment and teaching programme. Additionally, it explored how hypoglycaemia impacts patients' everyday life and the differences between individuals with and without impaired awareness of hypoglycaemia (IAH).

METHODS

This cross-sectional study included 340 adult participant with type 1 (n = 156) or type 2 diabetes (n = 184) undergoing insulin therapy at the University Hospital Jena. Participants completed validated questionnaires and participated in structured interviews about hypoglycaemia. Awareness of hypoglycaemia was measured using the Gold Score, and diabetes distress with the PAID Scale (PAID Score 0-100, the higher the score the higher the distress).

RESULTS

23.8% of the participants treated hypoglycaemia adequately (type 1 diabetes 27.6% vs. type 2 diabetes 24.7%; p = 0.606). Significantly more people without IAH-treated hypoglycaemia adequately in type 2 (27.9% vs. 10.3%; p = 0.047) but not in type 1 diabetes (28.6% vs. 23.1%; p = 0.568). Hypoglycaemia altered daily routines for 26.2% of participants, particularly those with type 1 diabetes (type 1 diabetes 37.3% vs. type 2 diabetes 20.1%; p = 0.001). People with type 1 and type 2 diabetes reporting changes in daily routines had higher diabetes distress scores (PAID: 22.3 ± 16.0 vs. 13.8 ± 13.5; p < 0.001). Fear of hypoglycaemia was associated with higher HbA values due to people accepting elevated blood glucose levels.

CONCLUSIONS

Despite education programmes, the majority of participants do not treat hypoglycaemia adequately. Hypoglycaemic events significantly impact daily life and are associated with increased diabetes-related distress, especially in those with IAH.

摘要

目的

调查1型和2型糖尿病患者在参加治疗与教学项目后是否能对低血糖症状做出充分反应。此外,研究低血糖如何影响患者的日常生活以及低血糖意识受损(IAH)患者与未受损患者之间的差异。

方法

这项横断面研究纳入了耶拿大学医院340名接受胰岛素治疗的1型(n = 156)或2型糖尿病(n = 184)成年参与者。参与者完成了经过验证的问卷,并参加了关于低血糖的结构化访谈。使用金氏评分测量低血糖意识,使用糖尿病痛苦量表(PAID量表,PAID评分0 - 100,分数越高痛苦程度越高)测量糖尿病痛苦。

结果

23.8%的参与者对低血糖的处理得当(1型糖尿病为27.6%,2型糖尿病为24.7%;p = 0.606)。在2型糖尿病中,无IAH的患者对低血糖处理得当的比例显著更高(27.9%对10.3%;p = 0.047),但在1型糖尿病中并非如此(28.6%对23.1%;p = 0.568)。低血糖改变了26.2%参与者的日常生活,尤其是1型糖尿病患者(1型糖尿病为37.3%,2型糖尿病为20.1%;p = 0.001)。报告日常生活有变化的1型和2型糖尿病患者的糖尿病痛苦评分更高(PAID:22.3±16.0对13.8±13.5;p < 0.001)。由于人们接受较高的血糖水平,对低血糖的恐惧与较高的糖化血红蛋白值相关。

结论

尽管有教育项目,但大多数参与者对低血糖的处理并不充分。低血糖事件显著影响日常生活,并与糖尿病相关痛苦增加有关,尤其是在IAH患者中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0869/12434433/7c073588a2e4/DME-42-e70121-g001.jpg

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