Department of Internal Diseases, Pauls Stradins University Hospital, Pilsonu Street 13, LV 1002 Riga, Latvia.
Department of Internal Diseases, Riga Stradins University, Dzirciema Street 16, LV 1007 Riga, Latvia.
Medicina (Kaunas). 2019 Sep 4;55(9):567. doi: 10.3390/medicina55090567.
Plasminogen activator inhibitor-1 (PAI-1) is a fibrinolytic system enzyme whose role in various fibrinolytic processes is currently unknown. In clinical manifestations of pleural liquids of diverse etiology, various levels of fibrinolytic activity can be observed-parapneumonic processes tend to loculate in fibrin septa, while malignant pleural effusion (MPE) does not. The purpose of this study was to determine possible differences in PAI-1 levels in pleural effusions of varied etiology.
PAI-1 level in pleural effusion and serum was determined in 144 patients with pleural effusions of various etiology (cardiac hydrothorax-42 patients (29.2%), MPE-67 patients (46.5%), parapneumonic pleuritis-27 (18.8%), tuberculous pleuritis-6 patients (4.1%), pancreatogenic pleuritis-1 patient (0.7%) and pulmonary artery thromboembolism with pleuritis-1 patient (0.7%)).
The median PAI-1 level (ng/mL) was the highest in the parapneumonic pleuritis group both in the effusion and the serum, with values of 291 (213-499) ng/mL and 204 (151-412) ng/mL, respectively, resulting in a statistically significant difference (p < 0.001) from the cardiac hydrothorax and MPE groups. However, there was no statistically significant difference between PAI-1 levels in the pleural effusion and serum in the cardiac hydrothorax and MPE groups.
The PAI-1 level in MPE and cardiac hydrothorax was statistically significantly lower than in parapneumonic pleuritis.
纤溶酶原激活物抑制剂-1（PAI-1）是一种纤维蛋白溶解系统酶，其在各种纤维蛋白溶解过程中的作用尚不清楚。在不同病因的胸腔液临床表现中，可以观察到不同程度的纤维蛋白溶解活性-类肺炎性胸腔积液倾向于在纤维蛋白隔中分隔，而恶性胸腔积液（MPE）则不会。本研究旨在确定不同病因胸腔积液中 PAI-1 水平的可能差异。
对 144 例不同病因胸腔积液患者（心源性胸腔积液 42 例（29.2%）、MPE 67 例（46.5%）、类肺炎性胸膜炎 27 例（18.8%）、结核性胸膜炎 6 例（4.1%）、胰源性胸膜炎 1 例（0.7%）和肺动脉血栓栓塞合并胸膜炎 1 例（0.7%））的胸腔积液和血清中的 PAI-1 水平进行了测定。
在胸腔积液和血清中，类肺炎性胸膜炎组的 PAI-1 水平（ng/mL）中位数最高，分别为 291（213-499）ng/mL 和 204（151-412）ng/mL，与心源性胸腔积液和 MPE 组相比差异具有统计学意义（p<0.001）。然而，在心源性胸腔积液和 MPE 组中，胸腔积液和血清中的 PAI-1 水平之间没有统计学差异。
MPE 和心源性胸腔积液中的 PAI-1 水平明显低于类肺炎性胸膜炎。
