Galkin R A, Popov A Iu
Probl Endokrinol (Mosk). 1988 Nov-Dec;34(6):13-8.
The time course of thyroid function and hypophyseal thyrotropic activity were investigated in 182 patients with diffuse toxic goiter of severe and moderately severe forms of thyrotoxicosis before operation and in short- and long-term periods after operation using radioimmunoassay in a hospital and outpatient clinic. The determination of blood T3, T4 and TSH at the height of clinical manifestations of thyrotoxicosis and before operation was shown to reflect the gravity of disease and could serve as a diagnostic test of the efficacy of preoperative preparation. A T4 concentration index varied at different time after operation. A considerable decrease in blood TSH on the first days after the operation and its rise in the following 6 mos. resulted from the patients' adaptation to new conditions and were of transient nature in the overwhelming majority of the patients. Final assessment of the thyroid and pituitary function was possible only 12 mos. after operation.
在一家医院和门诊诊所，采用放射免疫分析法，对182例重度和中度重度甲状腺毒症型弥漫性毒性甲状腺肿患者术前以及术后短期和长期的甲状腺功能及垂体促甲状腺素活性的时间进程进行了研究。结果显示，在甲状腺毒症临床表现高峰期及术前测定血T3、T4和TSH，可反映疾病的严重程度，并可作为术前准备效果的诊断性检测。术后不同时间T4浓度指数有所变化。术后头几天血TSH显著下降，随后6个月又升高，这是患者对新情况的适应所致，绝大多数患者的这种变化是暂时的。只有在术后12个月才能对甲状腺和垂体功能进行最终评估。
