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与白细胞介素-17抗体（IL-17Ab）对痛风性炎症发作时循环调节性T细胞/辅助性T细胞17（Treg/Th17）及浸润炎性单核细胞的调节相关的深入免疫表型分析数据。

In-depth immunophenotyping data relating to IL-17Ab modulation of circulating Treg/Th17 cells and of infiltrated inflammatory monocytes in the onset of gouty inflammation.

作者信息

Raucci Federica, Iqbal Asif J, Saviano Anella, Casillo Gian Marco, Russo Marina, Lezama Danielle, Mascolo Nicola, Maione Francesco

机构信息

ImmunoPharmaLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131, Naples, Italy.

Institute of Cardiovascular Sciences (ICVS), College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.

出版信息

Data Brief. 2019 Aug 12;25:104381. doi: 10.1016/j.dib.2019.104381. eCollection 2019 Aug.

DOI:10.1016/j.dib.2019.104381
PMID:31489355
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6717213/
Abstract

The data supplied in this work are related to the research article entitled "IL-17A neutralizing antibody regulates monosodium urate crystal-induced gouty inflammation" [1]. This data article presents the results of the gating strategy applied to identify Treg population in peripheral blood of mice injected with MSU crystals and MSU crystals + interleukin-17 antibody (IL-17Ab). Lastly, this article provides in-depth immunophenotyping data relating to all specific and isotype control antibodies used in the phenotypical characterization of circulating Treg (defined as CD4CD25Foxp3), Th17 (defined as CD4IL-17) cells and joint-infiltrated () inflammatory monocytes (defined as B220GR1F480CD115).

摘要

本研究提供的数据与题为《IL-17A 中和抗体调节尿酸钠晶体诱导的痛风性炎症》的研究文章相关[1]。本数据文章展示了用于鉴定注射尿酸钠晶体和尿酸钠晶体 + 白细胞介素 -17 抗体（IL-17Ab）的小鼠外周血中调节性 T 细胞群体的门控策略结果。最后，本文提供了与循环调节性 T 细胞（定义为 CD4CD25Foxp3）、辅助性 T 细胞 17（定义为 CD4IL-17）细胞以及关节浸润的（）炎性单核细胞（定义为 B220GR1F480CD115）表型特征分析中使用的所有特异性和同型对照抗体相关的深入免疫表型数据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/730f/6717213/2078b28bc9be/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/730f/6717213/3100ff723daf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/730f/6717213/926453e92659/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/730f/6717213/2078b28bc9be/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/730f/6717213/3100ff723daf/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/730f/6717213/926453e92659/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/730f/6717213/2078b28bc9be/gr3.jpg

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2
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Molecules. 2020 Dec 18;25(24):6016. doi: 10.3390/molecules25246016.
白细胞介素-17 在小鼠气囊中重复暴露有利于募集炎症性单核细胞，并在炎症液中释放白细胞介素-16 和 TREM-1。
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