ImmunoPharmaLab, Department of Pharmacy, School of Medicine and Surgery, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
Institute of Cardiovascular Sciences (ICVS), College of Medical and Dental Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Molecules. 2020 Dec 18;25(24):6016. doi: 10.3390/molecules25246016.
Several natural-based compounds and products are reported to possess anti-inflammatory and immunomodulatory activity both in vitro and in vivo. The primary target for these activities is the inhibition of eicosanoid-generating enzymes, including phospholipase A2, cyclooxygenases (COXs), and lipoxygenases, leading to reduced prostanoids and leukotrienes. Other mechanisms include modulation of protein kinases and activation of transcriptases. However, only a limited number of studies and reviews highlight the potential modulation of the coupling enzymatic pathway COX-2/mPGES-1 and Th17/Treg circulating cells. Here, we provide a brief overview of natural products/compounds, currently included in the Italian list of botanicals and the BELFRIT, in different fields of interest such as inflammation and immunity. In this context, we focus our opinion on novel therapeutic targets such as COX-2/mPGES-1 coupling enzymes and Th17/Treg circulating repertoire. This paper is dedicated to the scientific career of Professor Nicola Mascolo for his profound dedication to the study of natural compounds.
几种基于天然的化合物和产品被报道具有抗炎和免疫调节活性，无论是在体外还是体内。这些活性的主要靶点是抑制花生四烯酸生成酶，包括磷脂酶 A2、环氧化酶（COXs）和脂氧合酶，从而减少前列腺素和白三烯。其他机制包括蛋白激酶的调节和转录酶的激活。然而，只有少数研究和综述强调了对 COX-2/mPGES-1 偶联酶和 Th17/Treg 循环细胞的潜在调节。在这里，我们简要概述了天然产物/化合物，它们目前被列入意大利的植物名录和 BELFRIT，涉及炎症和免疫等不同领域。在这方面，我们专注于 COX-2/mPGES-1 偶联酶和 Th17/Treg 循环库等新的治疗靶点。本文献给尼古拉·马斯科洛教授的科学生涯，他为研究天然化合物做出了深远的贡献。
