Groza P, Artino-Rădulescu M, Nicolescu E
Physiologie. 1988 Oct-Dec;25(4):161-8.
Our previous studies dealt with the dynamics of the fluid-coagulant equilibrium in rats after confinement hypokinesia (CHK) for 1, 2 and 3 weeks obtained by placing them in small cages permitting only slight movements for spontaneous feeding. We found an acceleration of blood coagulation and fibrinolysis, with a maximal response after 1-2 weeks. In this work attention focussed on the initial more dynamic interval of 1, 3 and 7 days of exposure to CHK. To find certain relations between the central vegetative stimuli and the peripheral responses, experiments were done on normal and adrenalectomized rats and plasma corticosterone, the main glucocorticoid in these species, was measured. CHK accelerated the Quick and the Howell time (QT and HT) and euglobulin lysis time (ELT) progressively, beginning with the first day of exposure. Adrenalectomy as such shortened these parameters, demonstrating an inhibitory action of corticoid hormones in normal conditions. Exposure to CHK of adrenalectomised rats emphasizes these inhibitions. We did not found evident correlations between plasma corticosterone and these processes. The number of thrombocytes had a similar evolution, but in adrenalectomised and CHK rats they increase.
我们之前的研究涉及将大鼠置于仅允许轻微活动以进行自发进食的小笼子中，使其处于限制运动性低动力状态（CHK）1、2和3周后，大鼠体内流体 - 凝血剂平衡的动态变化。我们发现血液凝固和纤维蛋白溶解加速，在1 - 2周后出现最大反应。在这项工作中，重点关注暴露于CHK的最初1、3和7天这个更具动态变化的时间段。为了找出中枢植物性刺激与外周反应之间的某些关系，对正常大鼠和肾上腺切除大鼠进行了实验，并测量了这些物种中的主要糖皮质激素——血浆皮质酮。从暴露的第一天开始，CHK逐渐加速奎克凝血时间和豪厄尔凝血时间（QT和HT）以及优球蛋白溶解时间（ELT）。肾上腺切除术本身缩短了这些参数，表明在正常情况下皮质激素具有抑制作用。肾上腺切除大鼠暴露于CHK会强化这些抑制作用。我们未发现血浆皮质酮与这些过程之间存在明显的相关性。血小板数量有类似的变化，但在肾上腺切除且处于CHK状态的大鼠中血小板数量增加。
