Groza P, Artino-Rădulescu M, Munteanu M
Institute of Normal and Pathological Physiology, Bucharest, Romania.
Rev Roum Physiol (1990). 1990 Jan-Mar;27(1):3-8.
Our previous experiments (14) (15) dealt with the dynamic of the fluid-coagulant equilibrium in rats after exposure to confinement hypokinesia (CHK) at different time intervals, 1, 3, 7, 21, 28 and 35 days. We found a decreased Quiq and Howell time (QT and HT) in some relation with the time of exposure, with a tendency to normalization after 21 days. The same evolution was shown by the number of thrombocytes and of the euglobulin lysis time (ELT). In this work we prolonged the exposure to CHK for 60 days, an interval after which a series of other functional parameters significantly approached initial control values (16). We found an important approach to normal values also with the QT, HT, Elt and with the number of thrombocytes. Concomitantly, the plasma concentration of corticosterone (the principal glucocorticoid of rats), that increased over shorter intervals, approached also control values after 60 days of exposure to CHK. Nevertheless, it can not explain the changes of coagulability, because it decreases after adrenalectomy but the QT, HT and thrombocytes are already decreased. For these and other reasons it results that the relation of adrenal hormones to coagulation needs be further clarified.
我们之前的实验（14）（15）研究了大鼠在不同时间间隔（1、3、7、21、28和35天）暴露于限制活动减退（CHK）后，其血液凝固平衡的动态变化。我们发现凝血酶原时间（QT）和活化部分凝血活酶时间（HT）在一定程度上随着暴露时间的延长而缩短，且在21天后有恢复正常的趋势。血小板数量和优球蛋白溶解时间（ELT）也呈现出相同的变化趋势。在本研究中，我们将大鼠暴露于CHK的时间延长至60天，在此之后，一系列其他功能参数显著接近初始对照值（16）。我们发现，QT、HT、ELT以及血小板数量也显著接近正常水平。同时，大鼠主要糖皮质激素皮质酮的血浆浓度在较短时间间隔内升高，但在暴露于CHK 60天后也接近对照值。然而，这并不能解释凝血功能的变化，因为肾上腺切除术后皮质酮浓度降低，但QT、HT和血小板数量已经下降。基于这些及其他原因，肾上腺激素与凝血之间的关系仍需进一步阐明。
