Aging changes of the testis in albino rat: light, electron microscopic, morphometric, immunohistochemical and biochemical study.
作者信息
Hussein S M, El-Fadaly A B, Metawea A G, Khaled B E A
机构信息
Anatomy and Embryology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Department of Anatomy, College of Medicine, Jouf University, Skaka, AlJouf, Saudi Arabia.
出版信息
Folia Morphol (Warsz). 2020;79(3):503-515. doi: 10.5603/FM.a2019.0102. Epub 2019 Sep 6.
BACKGROUND
Aging has a deleterious effect on the morphology of the male reproductive system which might, in turn, lead to changes in spermatogenesis and consequently, decrease in both quality and quantity of spermatozoa.
MATERIALS AND METHODS
The present study elucidated the histological and ultrastructural changes of testes of adult albino rats during aging and applied morphometric measures to obtain quantitative data for these changes. The oxidative and antioxidative markers of aged testes were also assessed.
RESULTS
The results documented the presence of age-related regressive structural changes of the testis accompanied with an increase in the apoptosis and a decrease in the proliferative capacity.
CONCLUSIONS
The biochemical results gave evidence of an imbalance between the oxidative damage and the antioxidant defence indicating increased oxidative stress of aged testis.
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