Department of Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Scand J Immunol. 2019 Dec;90(6):e12823. doi: 10.1111/sji.12823. Epub 2019 Oct 7.
Sepsis is associated with significant mortality. Early diagnosis and prognosis of patients with sepsis is still a difficult clinical challenge. In this study, the ability of plasma PTX3 (pentraxin 3), MCP1 (monocyte chemoattractant protein 1) and Ang (angiopoietin)1/2 was investigated to evaluate the severity of sepsis. Blood samples were obtained from 43 patients with sepsis. A total of 33 post-surgery patients with infections and 25 healthy individuals served as controls. The results showed that plasma PTX3, MCP1 and Ang2 significantly increased in patients on the first day of septic shock onset, while sepsis patients had significantly higher Ang2 level, compared with controls. Furthermore, PTX3, MCP1 and Ang2 had high AUROC values in patients with septic shock on the first day of sepsis onset. The findings suggest that PTX3, MCP1 and Ang2 maybe early predictors to evaluate the severity of sepsis and septic shock with the latest Sepsis 3.0 definitions.
脓毒症与高死亡率相关。脓毒症患者的早期诊断和预后仍然是一个具有挑战性的临床难题。在这项研究中，我们研究了血浆 PTX3（五聚素 3）、MCP1（单核细胞趋化蛋白 1）和 Ang（血管生成素）1/2 对评估脓毒症严重程度的能力。采集了 43 例脓毒症患者的血液样本。共有 33 例术后感染患者和 25 名健康个体作为对照。结果显示，在脓毒性休克发病的第一天，血浆 PTX3、MCP1 和 Ang2 明显升高，而脓毒症患者的 Ang2 水平明显高于对照组。此外，PTX3、MCP1 和 Ang2 在脓毒症发病第一天的脓毒性休克患者中具有较高的 AUROC 值。这些发现表明，PTX3、MCP1 和 Ang2 可能是最新的 Sepsis 3.0 定义下评估脓毒症和脓毒性休克严重程度的早期预测指标。
