Institute of Home and Food Sciences, Government College University, Faisalabad, Pakistan.
Center for Precision Medicine, School of Medicine and School of Biomedical Sciences, Huaqiao University, Xiamen, China.
J Food Biochem. 2019 Sep;43(9):e12983. doi: 10.1111/jfbc.12983. Epub 2019 Jul 21.
Peripheral nerve injury is one of the major health concerns of the present era which can lead to the long-lasting disability and even demise. Currently, no effective and side effect free remedy exists and exploration of effective therapeutic strategies to regain functional outcome is a need of hour. In the present study, we used BALB/c mice (N = 14 age, 10-12 weeks & weight 32-34 g) that were divided into two groups: Normal chow (n = 7) and Fennel chow (n = 7) group. Here, we have explored the role of crude Foeniculum vulgare mill seeds in promoting functional recovery following a mechanical insult to the sciatic nerve by an oral administration of a crude dose of 500 mg/kg BW. The recovery of both sensory and motor functions was significantly (p > .05) accelerated in the treatment group, assessed by behavioral analyses alongside total antioxidant capacity increase. Conclusively, F. vulgare can be a potential therapeutic candidate for accelerating functional recovery after peripheral nerve injury. PRACTICAL APPLICATIONS: The outcomes of study have vital practical application both for scientists and consumers. The therapeutic role of phytochemicals on functional recovery has not been explored yet. This study will help figure out plant based regimen as booster for brain health and intervention against traumatic nerve injuries. Moreover, it may also attract the food and pharmaceutical industries to formulate cost effective therapeutic products. Likewise, it can prove instrumental for scientists for advance research on this aspect with more mechanistic targets.
周围神经损伤是当今时代的主要健康关注点之一，可导致长期残疾甚至死亡。目前，尚无有效的、无副作用的治疗方法，探索有效的治疗策略以恢复功能是当务之急。在本研究中，我们使用 BALB/c 小鼠（N = 14，年龄 10-12 周，体重 32-34 克）分为两组：正常饲料组（n = 7）和茴香饲料组（n = 7）。在这里，我们通过口服 500mg/kg BW 的粗剂量，探索了粗制茴香种子在机械损伤坐骨神经后促进功能恢复的作用。通过行为分析和总抗氧化能力的增加，治疗组的感觉和运动功能恢复明显（p >.05）加快。总之，F. vulgare 可能是促进周围神经损伤后功能恢复的潜在治疗候选药物。
该研究的结果对科学家和消费者都具有重要的实际应用价值。植物化学物质对功能恢复的治疗作用尚未得到探索。这项研究将有助于确定基于植物的方案作为大脑健康的促进剂和对创伤性神经损伤的干预措施。此外，它还可能吸引食品和制药行业来制定具有成本效益的治疗产品。同样，它可以为科学家提供更具机制性目标的这方面的先进研究的工具。
