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P1G10，一种来源于 的蛋白水解片段，可刺激急性紫外线 B 辐射暴露后的组织修复。

P1G10, the Proteolytic Fraction from , Stimulates Tissue Repair after Acute Exposure to Ultraviolet B Radiation.

机构信息

Departamento de Farmacologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Av Antônio Carlos 6627, Belo Horizonte 31270-901, MG, Brazil.

Faculdade de Medicina do Mucuri, Universidade Federal dos Vales do Jequitinhonha e Mucuri, Rua do Cruzeiro, nº 01, Bairro Jardim São Paulo, Teófilo Otoni 39803-371, MG, Brazil.

出版信息

Int J Mol Sci. 2019 Sep 6;20(18):4373. doi: 10.3390/ijms20184373.

DOI:10.3390/ijms20184373
PMID:31489890
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6770601/
Abstract

BACKGROUND: P1G10 is a cysteine proteolytic fraction from latex, obtained by chromatographic separation on Sephadex-G10 and ultrafiltration. This fraction enhances healing in different models of skin lesions, and displays a protective/healing effect against gastric ulcers, where it was suggested an antioxidant role. METHODS: We evaluated here the effect of topical treatment with P1G10, in mice lesions induced by UVB. RESULTS: After single exposure to 2.4 J cm UVB, P1G10 reduced erythema, increased cellularity of hypodermis, enhanced MPO activity and IL1β, and inhibited COX levels. These results point to an anti-inflammatory effect by P1G10. This fraction displayed antioxidant activity by reversing the depletion of glutathione (GSH), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD) and reducing the catalase activity increased by UVB. These changes may be related to a reduction in MDA observed in groups treated with P1G10. P1G10 also inhibited MMP-9, caspase-3 and pkat while increasing p53 levels.

摘要

背景：P1G10 是从乳胶中分离得到的半胱氨酸蛋白水解物，通过 Sephadex-G10 色谱分离和超滤获得。该部分在不同的皮肤损伤模型中增强愈合，并显示出对胃溃疡的保护/愈合作用，其中提示具有抗氧化作用。

方法：我们在这里评估了 P1G10 对 UVB 诱导的小鼠损伤的局部治疗效果。

结果：单次暴露于 2.4 J cm 的 UVB 后，P1G10 可减少红斑，增加真皮细胞的数量，增加 MPO 活性和 IL1β，并抑制 COX 水平。这些结果表明 P1G10 具有抗炎作用。该部分通过逆转 UVB 引起的谷胱甘肽 (GSH)、谷胱甘肽过氧化物酶 (GSH-Px)、超氧化物歧化酶 (SOD) 的消耗和减少增加的过氧化氢酶活性显示出抗氧化活性。这些变化可能与用 P1G10 处理的组中观察到的 MDA 减少有关。P1G10 还抑制 MMP-9、caspase-3 和 pkat，同时增加 p53 水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/74934cd20521/ijms-20-04373-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/082a00f9c042/ijms-20-04373-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/c78a48e4071d/ijms-20-04373-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/b92dd21a57f8/ijms-20-04373-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/e20aabb61ba6/ijms-20-04373-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/714d4be60775/ijms-20-04373-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/7f1191028ff2/ijms-20-04373-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/5c5556be9b3f/ijms-20-04373-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/cb88fa3bfb6b/ijms-20-04373-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/74934cd20521/ijms-20-04373-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/082a00f9c042/ijms-20-04373-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/c78a48e4071d/ijms-20-04373-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/b92dd21a57f8/ijms-20-04373-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/e20aabb61ba6/ijms-20-04373-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/714d4be60775/ijms-20-04373-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/7f1191028ff2/ijms-20-04373-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/5c5556be9b3f/ijms-20-04373-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/cb88fa3bfb6b/ijms-20-04373-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e000/6770601/74934cd20521/ijms-20-04373-g009.jpg

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P1G10, the Proteolytic Fraction from , Stimulates Tissue Repair after Acute Exposure to Ultraviolet B Radiation.

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[3]
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[2]
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本文引用的文献

[1]
Ozone-climate interactions and effects on solar ultraviolet radiation.

Photochem Photobiol Sci. 2019-2-27

[2]
Evaluation of the UVB-screening capacity and restorative effects exerted by farnesol gel on UVB-caused sunburn.

Environ Toxicol. 2018-4

[3]
Nanodesign of new self-assembling core-shell gellan-transfersomes loading baicalin and in vivo evaluation of repair response in skin.

Nanomedicine. 2017-12-15

[4]
UV-Induced Molecular Signaling Differences in Melanoma and Non-melanoma Skin Cancer.

Adv Exp Med Biol. 2017

[5]
Healing activity of proteolytic fraction (P1G10) from Vasconcellea cundinamarcensis in a cutaneous wound excision model.

Biomed Pharmacother. 2017-10-6

[6]
Protease loaded permeation enhancer liposomes for treatment of skin fibrosis arisen from second degree burn.

Biomed Pharmacother. 2017-8-8

[7]
Qa-2 expression levels is related with tumor-infiltrating lymphocytes profile during solid Ehrlich tumor development.

Biomed Pharmacother. 2017-6-4

[8]
Myeloperoxidase: A new player in autoimmunity.

Cell Immunol. 2017-7

[9]
UVB promotes the initiation of uveitic inflammatory injury in vivo and is attenuated by UV-blocking protection.

Mol Vis. 2017-4-12

[10]
IL-1R1-MyD88 axis elicits papain-induced lung inflammation.

Eur J Immunol. 2016-9-22

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