Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Mayurbhanj 757086, India.
Department of Pharmacy, Shri Venkateshwara University, NH-24, Rajabpur, Gajraula, Amroha 244236, Uttar Pradesh, India.
Curr Pharm Des. 2019;25(31):3406-3416. doi: 10.2174/1381612825666190906164003.
Hydroxyapatite (HAp) is a biocompatible bioceramic compound by nature and widely utilized in a broad range of biomedical applications, especially in drug delivery, tissue engineering, orthopedics, dentistry, etc. To intensify its usage, HAp is being reinforced with different biopolymer(s). In these bioceramicbiopolymeric systems, HAp crystallites have been well inviolate with the alginate molecules. The objective of this review article is to present a comprehensive discussion of different recently researched drug-releasing potential by HAp-alginate based matrices.
During past few years, HAp particles (both synthesized and naturally derived) have been reinforced within different alginate-based systems to load a variety of drug candidates. Most of the reported drug-releasing HAp-alginate based matrices were prepared by the methodology of ionic-gelation of sodium alginate followed by air-drying/spray drying process.
HAp-alginate systems have already been proved as useful for loading a variety of drugs and also resulting sustained drug delivery with minimizing the drawbacks of pure alginate matrices (such as burst drug-releasing and low mechanical property in the alkaline pH).
HAp-alginate composites loaded with different kinds of drugs have already been reported to exhibit sustained releasing of loaded drugs over a longer period.
羟基磷灰石（HAp）本质上是一种生物相容性的生物陶瓷化合物，广泛应用于广泛的生物医学应用，特别是在药物输送、组织工程、骨科、牙科等领域。为了增强其用途，HAp 正在与不同的生物聚合物（s）结合使用。在这些生物陶瓷-生物聚合物系统中，HAp 晶体已被藻酸盐分子完好地保护。本文的目的是全面讨论基于 HAp-藻酸盐的基质的不同最近研究的药物释放潜力。
在过去的几年中，HAp 颗粒（合成的和天然衍生的）已被增强到不同的藻酸盐基系统中，以负载各种药物候选物。大多数报道的药物释放 HAp-藻酸盐基基质是通过藻酸钠的离子凝胶化方法制备的，然后进行空气干燥/喷雾干燥。
HAp-藻酸盐系统已被证明可用于负载多种药物，同时最小化纯藻酸盐基质的缺点（如药物突释和碱性 pH 值下的机械性能低），从而实现持续的药物释放。
已报道负载不同种类药物的 HAp-藻酸盐复合材料可在较长时间内持续释放负载药物。
