Chemical Engineering Department, Istanbul Technical University, ITU Ayazaga Kampusu, Maslak, Istanbul, 34469, Turkey.
J Mater Sci Mater Med. 2017 Oct 6;28(11):180. doi: 10.1007/s10856-017-5961-0.
Hydroxyapatite (HAp) is a bioceramic applied in the biomedical areas, such as matrices for drug release control. Chitosan (CTS), a natural polymer, is another material has been widely investigated for its potential use in the drug delivery systems. In this study, the composites of HAp-CTS are produced in order to investigate their drug loading and release studies. First of all, HAp-CTS composites are produced in the presence of simulated body fluid (SBF). Analysis confirmed the structure of HAp-CTS composites. Secondly, composites are encapsulated with 5-Fluorouracil (5-FU). The weight ratio of CTS is varied to realize its effect on drug loading of 5-Fluorouracil, a cancer drug, for the ratios of 1:1, 1:2 and 1:4 of HAp-CTS. The weight ratio giving the greatest drug load efficiency is selected for the last step of the study. Crosslinking agent, glutaraldehyde, are changed from 0 to 5% on the selected sample, then, drug loading is examined again in various environment owing different pH. Furthermore, drug release studies are conducted. To understand the structure and morphology of the samples, XRD, FTIR, SEM and Uv-Spectrum are applied. It is observed that weight ratio of polymer and crosslinking agent can be manipulated to adjust drug loading. Release kinetics are shown the Fickian diffusion. This new produced material can be applicable for drug delivery.
羟基磷灰石（HAp）是一种应用于生物医学领域的生物陶瓷，例如药物释放控制的基质。壳聚糖（CTS）是一种天然聚合物，因其在药物传递系统中的潜在应用而受到广泛研究。在这项研究中，制备了 HAp-CTS 复合材料，以研究其药物负载和释放研究。首先，在模拟体液（SBF）存在下制备了 HAp-CTS 复合材料。分析证实了 HAp-CTS 复合材料的结构。其次，用 5-氟尿嘧啶（5-FU）包封复合材料。改变 CTS 的重量比，以实现其对癌症药物 5-氟尿嘧啶的药物负载的影响，HAp-CTS 的比例为 1:1、1:2 和 1:4。选择在所选样品中添加 0 至 5%的交联剂戊二醛，以获得最大药物负载效率的重量比，然后在不同 pH 值的各种环境中再次检查药物负载。此外，进行了药物释放研究。为了了解样品的结构和形态，应用了 XRD、FTIR、SEM 和 Uv 光谱。可以观察到可以操纵聚合物和交联剂的重量比来调节药物负载。释放动力学表现为菲克扩散。这种新生产的材料可适用于药物传递。
