基于核酸的 1 型糖尿病治疗策略。

Nucleic acid-based theranostics in type 1 diabetes.

机构信息

Precision Health Program, Department of Radiology, College of Human Medicine, Michigan State University, East Lansing, Michigan; College of Natural Science, Michigan State University, East Lansing, Michigan.

Precision Health Program, Department of Radiology, College of Human Medicine, Michigan State University, East Lansing, Michigan.

出版信息

Transl Res. 2019 Dec;214:50-61. doi: 10.1016/j.trsl.2019.08.006. Epub 2019 Aug 21.

DOI:10.1016/j.trsl.2019.08.006

PMID:31491371

Abstract

Application of RNAi interference for type 1 diabetes (T1D) therapy bears tremendous potential. This review will discuss vehicles for oligonucleotide delivery, imaging modalities used for delivery monitoring, therapeutic targets, and different theranostic strategies that can be applied for T1D treatment.

摘要

RNAi 干扰在 1 型糖尿病 (T1D) 治疗中的应用具有巨大的潜力。本文将讨论寡核苷酸递药载体、递药监测中使用的成像方式、治疗靶点以及可应用于 T1D 治疗的不同诊疗策略。