Richards Taylor Marie, Sun Aixia, Hayat Hasaan, Robertson Neil, Zhang Zhaoda, Fan Jinda, Wang Ping
Precision Health Program, Michigan State University, East Lansing, MI 48823, USA.
Department of Radiology, College of Human Medicine, Michigan State University, East Lansing, MI 48824, USA.
Life (Basel). 2020 Sep 19;10(9):213. doi: 10.3390/life10090213.
Islet transplantation has great potential as a cure for type 1 diabetes. At present; the lack of a clinically validated non-invasive imaging method to track islet grafts limits the success of this treatment. Some major clinical imaging modalities and various molecular probes, which have been studied for non-invasive monitoring of transplanted islets, could potentially fulfill the goal of understanding pathophysiology of the functional status and viability of the islet grafts. In this current review, we summarize the recent clinical studies of a variety of imaging modalities and molecular probes for non-invasive imaging of transplanted beta cell mass. This review also includes discussions on in vivo detection of endogenous beta cell mass using clinical imaging modalities and various molecular probes, which will be useful for longitudinally detecting the status of islet transplantation in Type 1 diabetic patients. For the conclusion and perspectives, we highlight the applications of multimodality and novel imaging methods in islet transplantation.
胰岛移植作为1型糖尿病的一种治疗方法具有巨大潜力。目前，缺乏一种经过临床验证的非侵入性成像方法来追踪胰岛移植，这限制了该治疗方法的成功。一些主要的临床成像模式和各种分子探针已被用于对移植胰岛进行非侵入性监测，它们有可能实现了解胰岛移植功能状态和存活能力的病理生理学这一目标。在本综述中，我们总结了近期关于多种成像模式和分子探针用于移植β细胞团非侵入性成像的临床研究。本综述还包括使用临床成像模式和各种分子探针进行内源性β细胞团体内检测的讨论，这将有助于纵向检测1型糖尿病患者的胰岛移植状态。在结论与展望部分，我们重点介绍了多模态和新型成像方法在胰岛移植中的应用。
