Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China.
College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China; State Key Laboratory of Resources and Environmental Information System, Institute of Geographic Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China.
Environ Int. 2019 Dec;133(Pt A):105135. doi: 10.1016/j.envint.2019.105135. Epub 2019 Sep 3.
Little information exists on the lipidemic effects of ozone exposure. Few studies have focused on the different patterns of the association among older adults population, and little attention has been given to comprehensive lipid indices when evaluating the effect of O3 exposure on the metabolism.
We conducted a longitudinal study involving 201 older adults in Beijing, China between 2016 and 2018. A mixed regression model was applied with random effects to investigate the relationship between O3 and lipid profiles.
O3 exposure positively correlated with TC, LDL-C, CRI-I, CRI-II and AC at short-term and medium-term exposure periods. The largest increases in TC, LDL-C, CRI-I and CRI-II were found in the 28-days moving average indicating accumulative effects over prolonged exposure period. A 10 μg/m increase of O3 at the 28-days moving average was associated with a significant increase of 3.9% (95% CI: 1.0, 6.9) in TC, 8.2% (95% CI: 4.2, 12.4) in LDL-C, 4.8% (95% CI: 1.1, 8.5) in CRI-I and 7.0% (95% CI: 2.7, 11.5) in CRI-II. Stratification by health status and characteristics revealed different patterns of lipid changes among older adults, lipid status, age, sex and BMI may modify the relationship between O3 exposure and lipid profiles.
Our findings suggest that short-term and medium-term O3 exposure is associated with lipid profiles abnormalities among the older adults. Evidence also suggests there are patterns within population which differ according to both health status and demographic characteristics.
关于臭氧暴露对血脂的影响，相关信息有限。少数研究集中在老年人群体之间关联的不同模式上，并且在评估 O3 暴露对代谢的影响时，很少关注综合脂质指标。
我们在中国北京进行了一项涉及 201 名老年人的纵向研究，时间跨度为 2016 年至 2018 年。采用随机效应混合回归模型来研究 O3 暴露与血脂谱之间的关系。
臭氧暴露与 TC、LDL-C、CRI-I、CRI-II 和 AC 在短期和中期暴露期呈正相关。在 28 天移动平均值中，TC、LDL-C、CRI-I 和 CRI-II 的增加幅度最大，表明在长时间暴露期间存在累积效应。在 28 天移动平均值中，O3 浓度每增加 10μg/m³，TC 显著增加 3.9%（95%CI：1.0，6.9），LDL-C 增加 8.2%（95%CI：4.2，12.4），CRI-I 增加 4.8%（95%CI：1.1，8.5），CRI-II 增加 7.0%（95%CI：2.7，11.5）。根据健康状况和特征进行分层，结果显示不同的老年人血脂变化模式。脂质状态、年龄、性别和 BMI 可能会改变 O3 暴露与脂质谱之间的关系。
我们的研究结果表明，短期和中期 O3 暴露与老年人的血脂谱异常有关。此外，证据表明人群中存在不同的模式，这些模式根据健康状况和人口统计学特征而有所不同。
