无叶乌头（Huth）全株中的 Acoapetaludines A-K、C 和 C-二萜生物碱
Acoapetaludines A-K, C and C-diterpenoid alkaloids from the whole plants of Aconitum apetalum (Huth) B.Fedtsch.
机构信息
State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, PR China; The Xinjiang Technical Institute of Physics & Chemistry, Chinese Academy of Sciences, Urumqi, 830011, PR China; University of Chinese Academy of Sciences, Yuquan Road 19, Beijing, 100049, PR China; State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550002, PR China.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 550014, PR China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences, Guiyang, 550002, PR China.
出版信息
Phytochemistry. 2019 Nov;167:112111. doi: 10.1016/j.phytochem.2019.112111. Epub 2019 Sep 3.
A C-diterpenoid alkaloid with an unprecedented carbon skeleton, acoapetaludine A, together with ten undescribed aconitine-type C-diterpenoid alkaloids, acoapetaludines B-K, were isolated from the whole plants of Aconitum apetalum (Huth) B. Fedtsch. (Ranunculaceae). The structures were elucidated based on a comprehensive spectroscopic data analysis. The absolute configuration of acoapetaludine A was determined by quantum ECD calculation. Acoapetaludines D and E exhibited weak anti-Helicobacter pylori activity at a minimum inhibitory concentration (MIC) of 100 and 50 μg/mL, respectively.
从短柄乌头（Huth）B. Fedtsch.（毛茛科）全植物中分离得到一个具有前所未有的碳骨架的 C-二萜生物碱，无瓣乌头定 A，以及十个未描述的乌头型 C-二萜生物碱，无瓣乌头定 B-K。基于全面的光谱数据分析阐明了这些结构。通过量子 ECD 计算确定了无瓣乌头定 A 的绝对构型。无瓣乌头定 D 和 E 在最低抑菌浓度（MIC）为 100 和 50μg/mL 时表现出微弱的抗幽门螺杆菌活性。
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