Hu Jiang, Li Jia-Xun, Li Qiang, Mao Xia, Peng Tian-Feng, Liu Hui-Qing, Yin Si, Yuan Hong-Jie
College of Biological Resources and Food Engineering, Qujing Normal University, Qujing 655011, China.
Tumor Hospital of Yunnan Province, The Third Affiliated Hospital of Kunming Medical University, Kunming 650118, China.
J Asian Nat Prod Res. 2022 Jul;24(7):617-623. doi: 10.1080/10286020.2021.1956907. Epub 2021 Jul 24.
A chemical investigation on the roots of afforded three undescribed aconitine-type C-diterpenoid alkaloids, episcopalines A-C (). The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated alkaloids were tested for their antinociceptive properties. As a result, episcopaline B () showed potent antinociceptive effect and its ID value (55.0 μmol/kg) was 2-fold less than those of the positive control drugs aspirin and acetaminophen.
对[植物名称]根进行的化学研究得到了三种未描述过的乌头碱型C-二萜生物碱，主教碱A - C（[具体结构简式]）。通过光谱分析（核磁共振、红外、紫外和质谱）阐明了这些新化合物的结构。对分离得到的生物碱进行了抗伤害感受特性测试。结果表明，主教碱B（[具体结构简式]）显示出强效的抗伤害感受作用，其半数抑制剂量值（55.0 μmol/kg）比阳性对照药物阿司匹林和对乙酰氨基酚低两倍。
