多囊卵巢综合征患者的棕色脂肪组织活性降低。

Brown adipose tissue activity is reduced in women with polycystic ovary syndrome.

机构信息

Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.

Odete Valadares Maternity Hospital, Fundação Hospitalar do Estado de Minas Gerais, Belo Horizonte, Brazil.

出版信息

Eur J Endocrinol. 2019 Nov;181(5):473-480. doi: 10.1530/EJE-19-0505.

DOI:10.1530/EJE-19-0505

PMID:31491743

Abstract

OBJECTIVE

To evaluate whether brown adipose tissue (BAT) activity is altered in women with polycystic ovary syndrome (PCOS), and whether BAT activity correlates with plasma levels of irisin, a myokine that can induce BAT formation.

DESIGN

We performed a cross-sectional study including women with PCOS (n = 45) and a healthy control group (n = 25) matched by age and body mass index (BMI).

METHODS

BAT activity was measured using 18F-FDG positron emission tomography-computed tomography (PET-CT) and plasma irisin levels were measured by a validated enzyme immunoassay.

RESULTS

Total BAT activity was significantly reduced in women with PCOS (maximal standardized uptake value (SUVmax): median 7.4 g/mL, interquartile range 0.9-15.4) compared to controls (median 13.0 g/mL, interquartile range 4.7-18.4, P = 0.047). However, this difference was no longer significant after adjustment for waist circumference, a surrogate marker of central adiposity. In the PCOS group, BAT activity correlated negatively with BMI (Spearman's r = -0.630, P = 0.000) and waist circumference (r = -0.592, P = 0.000) but not with plasma irisin levels.

CONCLUSIONS

BAT activity was reduced in women with PCOS possibly due to increased central adiposity. In PCOS women, BAT activity did not correlate with plasma irisin levels.

摘要

目的

评估多囊卵巢综合征（PCOS）妇女的棕色脂肪组织（BAT）活性是否改变，以及 BAT 活性是否与肌因子鸢尾素的血浆水平相关，鸢尾素可以诱导 BAT 形成。

设计

我们进行了一项横断面研究，纳入了 45 名 PCOS 妇女（n = 45）和 25 名年龄和体重指数（BMI）匹配的健康对照组。

方法

使用 18F-FDG 正电子发射断层扫描-计算机断层扫描（PET-CT）测量 BAT 活性，并通过经过验证的酶联免疫吸附测定法测量血浆鸢尾素水平。

结果

与对照组（中位数 13.0 g/mL，四分位距 4.7-18.4）相比，PCOS 妇女的总 BAT 活性明显降低（最大标准化摄取值（SUVmax）：中位数 7.4 g/mL，四分位距 0.9-15.4，P = 0.047）。然而，在校正腰围后（中央肥胖的替代标志物），这种差异不再显著。在 PCOS 组中，BAT 活性与 BMI（Spearman's r = -0.630，P = 0.000）和腰围（r = -0.592，P = 0.000）呈负相关，但与血浆鸢尾素水平无关。