Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
Odete Valadares Maternity Hospital, Fundação Hospitalar do Estado de Minas Gerais, Belo Horizonte, Brazil.
Horm Metab Res. 2020 Oct;52(10):718-723. doi: 10.1055/a-1157-0615. Epub 2020 May 4.
Polycystic ovary syndrome (PCOS) is a chronic dysfunction associated with obesity and metabolic disorders that can be ameliorated by treatment with metformin. Brown adipose tissue (BAT) has been recently identified in adult humans, and irisin is a myokine that induces BAT formation. The aim of this randomized controlled trial was to evaluate whether a short term treatment with metformin alters BAT activity and plasma irisin levels in women with PCOS. The participants were randomly assigned to receive metformin (1500 mg/day, n=21) or placebo (n=24) during 60 days. BAT activity was assessed by F-FDG positron emission tomography-computed tomography (PET-CT) and plasma irisin levels were measured by enzyme immunoassay. The groups were similar in age, body measures, metabolic profile and PCOS phenotypes. BAT activity did not change significantly in the women treated with metformin (median Δ SUV=-0.06 g/ml, interquartile interval -2.81 to 0.24 g/ml, p=0.484, Wilcoxon's test) or placebo (median Δ SUV=0.98 g/ml, interquartile interval -2.94 to 4.60 g/ml, p=0.386). In addition, plasma irisin levels remained unchanged in the groups treated with metformin (median Δ=-98 ng/ml, interquartile interval -366 to 60 ng/ml, p=0.310) and placebo (median Δ=28 ng/ml, interquartile interval -1260 to 215 ng/ml, p=0.650). These results suggest that in PCOS women BAT activity and plasma irisin levels may not change after a brief treatment with metformin.
多囊卵巢综合征（PCOS）是一种与肥胖和代谢紊乱相关的慢性功能障碍，可以通过二甲双胍治疗得到改善。棕色脂肪组织（BAT）最近在成年人体内被发现，而鸢尾素是一种肌因子，可诱导 BAT 形成。本随机对照试验的目的是评估短期使用二甲双胍是否会改变 PCOS 妇女的 BAT 活性和血浆鸢尾素水平。参与者被随机分配接受二甲双胍（1500mg/天，n=21）或安慰剂（n=24）治疗 60 天。通过 F-FDG 正电子发射断层扫描-计算机断层扫描（PET-CT）评估 BAT 活性，通过酶联免疫吸附测定法测量血浆鸢尾素水平。两组在年龄、身体测量、代谢特征和 PCOS 表型方面相似。接受二甲双胍治疗的妇女的 BAT 活性没有显著变化（中位数 Δ SUV=-0.06g/ml，四分位距 -2.81 至 0.24g/ml，p=0.484，Wilcoxon 检验）或安慰剂（中位数 Δ SUV=0.98g/ml，四分位距 -2.94 至 4.60g/ml，p=0.386）。此外，接受二甲双胍治疗的组血浆鸢尾素水平保持不变（中位数 Δ=-98ng/ml，四分位距 -366 至 60ng/ml，p=0.310）和安慰剂（中位数 Δ=28ng/ml，四分位距 -1260 至 215ng/ml，p=0.650）。这些结果表明，在 PCOS 妇女中，BAT 活性和血浆鸢尾素水平在接受短暂的二甲双胍治疗后可能不会改变。
