Armstrong Alissa Richmond
Department of Biological Sciences, University of South Carolina, Columbia, South Carolina, USA.
Reproduction. 2020 Feb;159(2):R69-R82. doi: 10.1530/REP-18-0593.
Observed in a wide variety of organism, from invertebrates to mammals, nutritional status modulates the energetically costly effort of producing female gametes. Despite this long-standing link between nutrition and ovarian function, relatively little is known about the cellular and molecular mechanisms that underlie how dietary components modulate egg production. Drosophila melanogaster, with its powerful and extensive genetic tools as well as its well-characterized ovarian response to diet, has proven to be instrumental in addressing this issue. This review covers what we currently know about the dietary control of oogenesis in Drosophila and the salient features of the fruit fly that make it a model for nutritional control of ovarian function.
从无脊椎动物到哺乳动物，在各种各样的生物体中都观察到，营养状况会调节产生雌配子所需的高能量消耗过程。尽管营养与卵巢功能之间存在这种长期联系，但对于饮食成分如何调节卵子产生的细胞和分子机制，我们了解得相对较少。黑腹果蝇拥有强大而广泛的遗传工具，以及其对饮食有充分表征的卵巢反应，已被证明在解决这个问题上发挥了重要作用。本综述涵盖了我们目前对果蝇卵子发生的饮食控制的了解，以及果蝇作为卵巢功能营养控制模型的显著特征。
