Yoshimura Yusuke, Ishijima Muneaki, Ishibashi Masayoshi, Liu Liz, Arikawa-Hirasawa Eri, Machida Shuichi, Naito Hisashi, Hamada Chieko, Kominami Eiki
Juntendo University School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421 Japan; Research Institute for Diseases of Old Age, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421 Japan.
Center of Innovation (COI) Program, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421 Japan; Department of Medicine for Orthopaedics and Motor Organ, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421 Japan; Sportology Center, Juntendo University Graduate School of Medicine, Hongo 2-1-1, Bunkyo-ku, Tokyo 113-8421 Japan.
J Orthop Sci. 2019 Nov;24(6):1094-1104. doi: 10.1016/j.jos.2019.08.009. Epub 2019 Sep 3.
We developed the Locomonitor application (app), the world's first iOS app to study locomotive syndrome, using the ResearchKit and examined the prevalence and risk factors for locomotive syndrome in Japanese general individuals 20-69 years old in a nationwide cross-sectional observational study.
The participants were recruited from February to August 2016. The outcome measures for the locomotive function were evaluated by locomotive syndrome risk tests (LSRTs) using the Locomonitor app. The chi-squared test, a linear-by-linear association trend analysis, and Spearman's correlation test were performed as statistical analyses.
A total of 2177 subjects from all prefectures in Japan were included (average 42.2 years old). The Locomo25 and Stand-Up test scores in female participants and the Two-Step test scores in male participants showed age-dependent deterioration. In the overall population, the incidence of Locomo stage 1 and 2, as evaluated by the Locomo25, Stand-Up test or Two-Step test, was 30.2% and 29.2%, respectively. In subjects without locomotive syndrome (40.5%), LSRT scores showed age-dependent deterioration in both sexes. Locomotive syndrome in participants with a body mass index (BMI) of ≥25 kg/m was more frequent than in those with a BMI of <25 kg/m (age- and gender-adjusted odds ratio [OR] 1.344 [95% confidence interval {CI} 1.03-1.75, p = 0.027]). Locomotive syndrome in participants with an exercise habit was less frequent than in those without an exercise habit (age- and gender-adjusted OR 0.499 [95% CI 0.33-0.755, p < 0.0001]).
The Locomonitor app, a newly developed remote platform, revealed that approximately 20%-30% of Japanese individuals 20-69 years old in the general population met the definition of locomotive syndrome. Locomotive syndrome in participants with obesity was more frequent than those without obesity, while locomotive syndrome in participants with an exercise habit was less frequent than those without an exercise habit.
我们使用ResearchKit开发了Locomonitor应用程序（应用），这是世界上首个用于研究机车综合征的iOS应用，并在一项全国性横断面观察性研究中，调查了20 - 69岁日本普通人群中机车综合征的患病率及危险因素。
研究对象于2016年2月至8月招募。使用Locomonitor应用通过机车综合征风险测试（LSRTs）评估机车功能的结果指标。采用卡方检验、线性 - 线性关联趋势分析和Spearman相关性检验进行统计分析。
共纳入来自日本所有县的2177名受试者（平均年龄42.2岁）。女性参与者的Locomo25和起立测试分数以及男性参与者的两步测试分数显示出年龄依赖性恶化。在总体人群中，通过Locomo25、起立测试或两步测试评估的Locomo 1期和2期的发生率分别为30.2%和29.2%。在无机车综合征的受试者中（40.5%），LSRT分数在男女两性中均显示出年龄依赖性恶化。体重指数（BMI）≥25 kg/m²的参与者中机车综合征的发生率高于BMI < 25 kg/m²的参与者（年龄和性别调整后的优势比[OR]为1.344 [95%置信区间{CI} 1.03 - 1.75，p = 0.027]）。有运动习惯的参与者中机车综合征的发生率低于无运动习惯的参与者（年龄和性别调整后的OR为0.499 [95% CI 0.33 - 0.755，p < 0.0001]）。
新开发的远程平台Locomonitor应用显示，普通人群中约20% - 30%的20 - 69岁日本个体符合机车综合征的定义。肥胖参与者中机车综合征的发生率高于非肥胖者，而有运动习惯的参与者中机车综合征的发生率低于无运动习惯者。
