Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, 712100, Yangling, Shaanxi, China.
Nat Commun. 2019 Sep 6;10(1):4039. doi: 10.1038/s41467-019-12066-z.
Antibiotic therapy is usually not recommended for salmonellosis, as it is associated with prolonged fecal carriage without reducing symptom duration or severity. Here we show that antibiotics encapsulated in hydrogen sulfide (HS)-responsive glycovesicles may be potentially useful for the treatment of salmonellosis. The antibiotics are released in the presence of Salmonella, which is known to produce HS. This approach prevents the quick absorption of antibiotics into the bloodstream, allows localized targeting of the pathogen in the gut, and alleviates disease symptoms in a mouse infection model. In addition, it reduces antibiotic-induced changes in the gut microbiota, and increases the abundance of potentially beneficial lactobacilli due to the release of prebiotic xylooligosaccharide analogs.
抗生素疗法通常不推荐用于沙门氏菌病，因为它与延长粪便携带期而不减少症状持续时间或严重程度有关。在这里，我们表明，包封在硫化氢（HS）响应糖囊泡中的抗生素可能对沙门氏菌病的治疗有用。在存在已知产生 HS 的沙门氏菌的情况下释放抗生素。这种方法可防止抗生素迅速被吸收到血液中，允许在肠道中对病原体进行局部靶向，并减轻小鼠感染模型中的疾病症状。此外，由于前体木寡糖类似物的释放，它减少了抗生素诱导的肠道微生物群变化，并增加了潜在有益的乳杆菌的丰度。
