College of Chemistry & Pharmacy, Shaanxi Key Laboratory of Natural Products & Chemical Biology, Northwest A&F University, Yangling 712100, Shaanxi, China.
Shandong Second Med Univ, Sch Biosci & Technol, Key Lab Biol Med Univ Shandong Prov, Baotong Rd, Weifang 261053, Shangdong, China.
Int J Biol Macromol. 2024 May;267(Pt 2):131656. doi: 10.1016/j.ijbiomac.2024.131656. Epub 2024 Apr 16.
The gut microbiota plays a significant role in the pathogenesis and remission of inflammatory bowel disease. However, conventional antibiotic therapies may alter microbial ecology and lead to dysbiosis of the gut microbiome, which greatly limits therapeutic efficacy. To address this challenge, novel nanomicelles that couple inulin with levofloxacin via disulfide bonds for the treatment of salmonellosis were developed in this study. Owing to their HS-responsiveness, the nanomicelles can target the inflamed colon and rapidly release levofloxacin to selectively fight against enteric pathogens. Moreover, the embedded inulin can serve as prebiotic fiber to increase the amount of Bifidobacteria and Lactobacilli in mice with salmonellosis, thus maintaining the intestinal mechanical barrier and regulating the balance of the intestinal flora. Therefore, multifunctional nanomicelles had a better curative effect than pure levofloxacin on ameliorating inflammation in vivo. The pathogen-targeted glycovesicle represents a promising drug delivery platform to maximize the efficacy of antibacterial drugs for the treatment of inflammatory bowel disease.
肠道微生物群在炎症性肠病的发病机制和缓解中起着重要作用。然而，传统的抗生素疗法可能会改变微生物生态，导致肠道微生物组的失调，这极大地限制了治疗效果。为了解决这一挑战，本研究开发了一种新型纳米胶束，该胶束通过二硫键将菊粉与左氧氟沙星偶联，用于治疗沙门氏菌病。由于其对 HS 的响应性，纳米胶束可以靶向发炎的结肠，并迅速释放左氧氟沙星以选择性地对抗肠道病原体。此外，嵌入的菊粉可以作为益生菌纤维，增加沙门氏菌感染小鼠体内双歧杆菌和乳酸杆菌的数量，从而维持肠道机械屏障并调节肠道菌群平衡。因此，多功能纳米胶束在改善体内炎症方面比纯左氧氟沙星具有更好的疗效。病原体靶向糖囊泡代表了一种有前途的药物递送平台，可以最大限度地提高抗菌药物治疗炎症性肠病的疗效。
