从白色到棕色——脂肪组织对生长激素突变小鼠的延长寿命和健康寿命至关重要。
From White to Brown - Adipose Tissue Is Critical to the Extended Lifespan and Healthspan of Growth Hormone Mutant Mice.
机构信息
Section on Integrative Physiology and Metabolism, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA.
Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield, IL, USA.
出版信息
Adv Exp Med Biol. 2019;1178:207-225. doi: 10.1007/978-3-030-25650-0_11.
Growth hormone (GH) is a metabolic hormone that has major functions in the liver, muscle, and adipose tissue (AT). In the past 20 years, numerous studies have demonstrated that decreased growth hormone (GH) action is clearly linked to alterations in longevity. Therefore, it is not surprising that mechanisms underlying the extended longevity of GH-mutant animals include alterations in AT function. This Review aims to describe the basics of AT biology, GH secretion and action, and the effects of altered GH signaling in mice and humans. Lastly, this Review discusses the intersection of GH and AT, and how the influence of GH on AT may play a critical role in determining lifespan and healthspan.
生长激素（GH）是一种代谢激素，在肝脏、肌肉和脂肪组织（AT）中具有重要功能。在过去的 20 年中，许多研究表明，生长激素（GH）作用的降低与长寿的改变明显相关。因此，并不奇怪的是，导致 GH 突变动物长寿的机制包括 AT 功能的改变。本综述旨在描述 AT 生物学、GH 分泌和作用以及改变的 GH 信号在小鼠和人类中的作用的基础知识。最后，本综述讨论了 GH 和 AT 的交集，以及 GH 对 AT 的影响如何在决定寿命和健康寿命方面发挥关键作用。
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