挑战“舒适”生活：产热和脂肪组织适应性在艾姆斯和斯内尔侏儒小鼠延缓衰老中的潜在作用
Challenging a "Cushy" Life: Potential Roles of Thermogenesis and Adipose Tissue Adaptations in Delayed Aging of Ames and Snell Dwarf Mice.
作者信息
Valencak Teresa G, Spenlingwimmer Tanja, Nimphy Ricarda, Reinisch Isabel, Hoffman Jessica M, Prokesch Andreas
机构信息
College of Animal Sciences, Zhejiang University, Zijingang Campus, 866 Yuhangtang Road, Hangzhou 310058, China.
Department of Biomedical Sciences, Institute of Physiology, Pathophysiology and Biophysics, University of Veterinary Medicine, Veterinärplatz 1, A-1210 Vienna, Austria.
出版信息
Metabolites. 2020 Apr 29;10(5):176. doi: 10.3390/metabo10050176.
Laboratory mouse models with genetically altered growth hormone (GH) signaling and subsequent endocrine disruptions, have longer lifespans than control littermates. As such, these mice are commonly examined to determine the role of the somatotropic axis as it relates to healthspan and longevity in mammals. The two most prominent mouse mutants in this context are the genetically dwarf Ames and Snell models which have been studied extensively for over two decades. However, it has only been proposed recently that both white and brown adipose tissue depots may contribute to their delayed aging. Here we review the current state of the field and supplement it with recent data from our labs.
具有生长激素（GH）信号基因改变及随后内分泌紊乱的实验室小鼠模型，其寿命比同窝对照小鼠更长。因此，通常会对这些小鼠进行研究，以确定生长激素轴在哺乳动物健康寿命和长寿方面的作用。在这种情况下，两个最著名的小鼠突变体是基因矮小的艾姆斯（Ames）和斯内尔（Snell）模型，二十多年来对它们进行了广泛研究。然而，直到最近才有研究提出，白色和棕色脂肪组织库可能都对它们的衰老延迟有影响。在此，我们综述该领域的现状，并补充我们实验室的最新数据。
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