Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, China.
Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, College of Chemistry, Fuzhou University, Fuzhou 350116, China; Marine Drug R&D Center, Institute of Oceanography, Minjiang University, Fuzhou 350108, China.
Int J Pharm. 2019 Oct 30;570:118663. doi: 10.1016/j.ijpharm.2019.118663. Epub 2019 Sep 4.
Nanoformulations with advantages in drug delivery, safety and pharmacodynamics have been booming as a promising strategy for cancer therapy. However, the traditional nanocarrier still suffers from the low drug loading capacity, potential systematic toxicity, unclear metabolism, and other uncertainties. To overcome these issues, carrier-free nanodrugs with desirable bioactivity were developed rapidly and drawn considerable attention. Meanwhile, the multifunctional self-delivery nanoarcheticture fabricated by a simple and "green" method, has significant advantages in synergistic cancer therapy and inhibition of multidrug resistant (MDR). Till now, carrier-free nanoparticles for tumor theranostics, phototherapy, chemotherapy, diagnose and synergistic therapy, have made outstanding progress. In this review, we make an integrated and exhaustive overview of lately reports on carrier-free nanodrug delivery systems formed by several active agents. We summarize the self-assembly and modified strategies, with emphasis on application superiority of carrier-free nanocrystal, and give new insight into the establishment of ideal nanosystems for cancer treatment.
具有药物传递、安全性和药效学优势的纳米制剂作为癌症治疗的一种有前途的策略正在蓬勃发展。然而，传统的纳米载体仍然存在药物载药量低、潜在的系统毒性、代谢不明确等不确定性。为了克服这些问题，具有理想生物活性的无载体纳米药物迅速发展并引起了广泛关注。同时，通过简单和“绿色”方法制备的多功能自递药纳米结构在协同癌症治疗和抑制多药耐药（MDR）方面具有显著优势。迄今为止，用于肿瘤治疗、光疗、化疗、诊断和协同治疗的无载体纳米颗粒已经取得了显著的进展。在这篇综述中，我们对由几种活性药物组成的无载体纳米药物传递系统的最新报告进行了综合和详尽的概述。我们总结了自组装和修饰策略，重点介绍了无载体纳米晶体的应用优势，并为建立理想的癌症治疗纳米系统提供了新的见解。
