• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

纳米技术在中药有效成分中的高级应用。

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines.

机构信息

State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-Di Herbs, Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China.

Department of Traditional Chinese Medical Science, Sixth Medical Center of the Chinese PLA General Hospital, Beijing, 100037, China.

出版信息

J Nanobiotechnology. 2023 Nov 29;21(1):456. doi: 10.1186/s12951-023-02165-x.

DOI:10.1186/s12951-023-02165-x
PMID:38017573
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10685519/
Abstract

Traditional Chinese Medicines (TCMs) have been used for centuries for the treatment and management of various diseases. However, their effective delivery to targeted sites may be a major challenge due to their poor water solubility, low bioavailability, and potential toxicity. Nanocarriers, such as liposomes, polymeric nanoparticles, inorganic nanoparticles and organic/inorganic nanohybrids based on active constituents from TCMs have been extensively studied as a promising strategy to improve the delivery of active constituents from TCMs to achieve a higher therapeutic effect with fewer side effects compared to conventional formulations. This review summarizes the recent advances in nanocarrier-based delivery systems for various types of active constituents of TCMs, including terpenoids, polyphenols, alkaloids, flavonoids, and quinones, from different natural sources. This review covers the design and preparation of nanocarriers, their characterization, and in vitro/vivo evaluations. Additionally, this review highlights the challenges and opportunities in the field and suggests future directions for research. Nanocarrier-based delivery systems have shown great potential in improving the therapeutic efficacy of TCMs, and this review may serve as a comprehensive resource to researchers in this field.

摘要

中药（TCM）已被用于治疗和管理各种疾病已有数百年的历史。然而，由于其水溶性差、生物利用度低以及潜在毒性，其有效递送至靶向部位可能是一个主要挑战。基于中药有效成分的纳米载体，如脂质体、聚合物纳米粒子、无机纳米粒子和有机/无机纳米杂化体，已被广泛研究作为一种有前途的策略，以改善中药有效成分的递送来实现更高的治疗效果，与传统制剂相比副作用更少。

本综述总结了基于纳米载体的中药各种类型有效成分（包括萜类、多酚类、生物碱类、黄酮类和醌类）的递药系统的最新进展，这些有效成分来自不同的天然来源。本综述涵盖了纳米载体的设计和制备、其表征以及体外/体内评价。此外，本综述还强调了该领域的挑战和机遇，并提出了未来的研究方向。

基于纳米载体的递药系统在提高中药的治疗效果方面显示出巨大的潜力，本综述可以作为该领域研究人员的综合资源。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/8d36e13229af/12951_2023_2165_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/937950a89aa1/12951_2023_2165_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/04d7939c4aa8/12951_2023_2165_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/0f3a1a6e4e9c/12951_2023_2165_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/9389c16fb97d/12951_2023_2165_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/cb2e5c8b53be/12951_2023_2165_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/cdb24b7e21e9/12951_2023_2165_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/a7263ef05b91/12951_2023_2165_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/159779cdd468/12951_2023_2165_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/8d36e13229af/12951_2023_2165_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/937950a89aa1/12951_2023_2165_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/04d7939c4aa8/12951_2023_2165_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/0f3a1a6e4e9c/12951_2023_2165_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/9389c16fb97d/12951_2023_2165_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/cb2e5c8b53be/12951_2023_2165_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/cdb24b7e21e9/12951_2023_2165_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/a7263ef05b91/12951_2023_2165_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/159779cdd468/12951_2023_2165_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2382/10685519/8d36e13229af/12951_2023_2165_Fig9_HTML.jpg

相似文献

1
Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines.纳米技术在中药有效成分中的高级应用。
J Nanobiotechnology. 2023 Nov 29;21(1):456. doi: 10.1186/s12951-023-02165-x.
2
Advanced Application of Polymer Nanocarriers in Delivery of Active Ingredients from Traditional Chinese Medicines.高分子纳米载体在中药活性成分传递中的高级应用。
Molecules. 2024 Jul 26;29(15):3520. doi: 10.3390/molecules29153520.
3
Research progress on nanotechnology for delivery of active ingredients from traditional Chinese medicines.中药活性成分传递用纳米技术的研究进展。
J Mater Chem B. 2020 Aug 5;8(30):6333-6351. doi: 10.1039/d0tb01260b.
4
Nano-traditional Chinese medicine: a promising strategy and its recent advances.纳米中药：一种有前景的策略及其最新进展
J Mater Chem B. 2022 Apr 20;10(16):2973-2994. doi: 10.1039/d2tb00225f.
5
Applications of Nanotechnology-mediated Herbal Nanosystems for Ophthalmic Drug.纳米技术介导的草药纳米系统在眼科药物中的应用。
Pharm Nanotechnol. 2024;12(3):229-250. doi: 10.2174/2211738511666230816090046.
6
Nanotechnology-Based Drug Delivery System for Anticancer Active Ingredients from Traditional Chinese Medicines: A Review.基于纳米技术的中药抗癌活性成分药物传递系统：综述。
Am J Chin Med. 2022;50(8):2011-2032. doi: 10.1142/S0192415X22500860.
7
Recent Advances in Nanotechnology-Based Targeted Delivery Systems of Active Constituents in Natural Medicines for Cancer Treatment.基于纳米技术的天然药物活性成分靶向传递系统在癌症治疗中的最新进展。
Molecules. 2023 Nov 24;28(23):7767. doi: 10.3390/molecules28237767.
8
Self-assembled nanodrug delivery systems for anti-cancer drugs from traditional Chinese medicine.自组装纳米药物递送系统用于中药抗癌药物。
Biomater Sci. 2024 Mar 26;12(7):1662-1692. doi: 10.1039/d3bm01451g.
9
Bidirectional effects and mechanisms of traditional Chinese medicine.中药的双向作用及其机制
J Ethnopharmacol. 2022 Nov 15;298:115578. doi: 10.1016/j.jep.2022.115578. Epub 2022 Jul 31.
10
Recent discovery of tyrosinase inhibitors in traditional Chinese medicines and screening methods.近年来从传统中药中发现的酪氨酸酶抑制剂及筛选方法。
J Ethnopharmacol. 2023 Mar 1;303:115951. doi: 10.1016/j.jep.2022.115951. Epub 2022 Nov 19.

引用本文的文献

1
Engineered Panax notoginseng polysaccharide micelles inhibit macrophage polarization and delay the progression of rheumatoid arthritis via JAK2-STAT3 signaling pathway.工程化三七多糖胶束通过JAK2-STAT3信号通路抑制巨噬细胞极化并延缓类风湿性关节炎的进展。
J Nanobiotechnology. 2025 Jul 14;23(1):509. doi: 10.1186/s12951-025-03576-8.
2
A comprehensive overview of triptolide utilizing nanotechnology and its potential applications in prostate diseases.雷公藤甲素利用纳米技术的全面概述及其在前列腺疾病中的潜在应用。
Front Pharmacol. 2025 Jun 17;16:1592066. doi: 10.3389/fphar.2025.1592066. eCollection 2025.
3
From Nature to Nanomedicine: Enhancing the Antitumor Efficacy of Rhein, Curcumin, and Resveratrol.

本文引用的文献

1
Research progress of traditional Chinese medicine as sensitizer in reversing chemoresistance of colorectal cancer.中药作为增敏剂逆转结直肠癌化疗耐药性的研究进展
Front Oncol. 2023 Mar 13;13:1132141. doi: 10.3389/fonc.2023.1132141. eCollection 2023.
2
Rosmarinic Acid-Crosslinked Supramolecular Nanoassembly with Self-Regulated Photodynamic and Anti-Metastasis Properties for Synergistic Photoimmunotherapy.迷迭香酸交联超分子纳米组装体具有自调控光动力和抗转移特性，用于协同光免疫治疗。
Small. 2023 Jun;19(23):e2300594. doi: 10.1002/smll.202300594. Epub 2023 Feb 8.
3
Polyethyleneglycol-Betulinic Acid (PEG-BA) Polymer-Drug Conjugate Induces Apoptosis and Antioxidation in a Biological Model of Pancreatic Cancer.
从天然产物到纳米医学：增强大黄酸、姜黄素和白藜芦醇的抗肿瘤功效
Medicina (Kaunas). 2025 May 26;61(6):981. doi: 10.3390/medicina61060981.
4
How Traditional Chinese Medicine Can Play a Role In Nanomedicine? A Comprehensive Review of the Literature.中医如何在纳米医学中发挥作用？文献综述
Int J Nanomedicine. 2025 May 20;20:6289-6315. doi: 10.2147/IJN.S518610. eCollection 2025.
5
Natural small molecules regulating the mitophagy pathway counteract the pathogenesis of diabetes and chronic complications.调节线粒体自噬途径的天然小分子可对抗糖尿病及其慢性并发症的发病机制。
Front Pharmacol. 2025 Apr 16;16:1571767. doi: 10.3389/fphar.2025.1571767. eCollection 2025.
6
Anticancer effects of salvianolic acid A through multiple signaling pathways (Review).丹酚酸A通过多条信号通路发挥抗癌作用（综述）。
Mol Med Rep. 2025 Jul;32(1). doi: 10.3892/mmr.2025.13541. Epub 2025 Apr 25.
7
Unassuming Lichens: Nature's Hidden Antimicrobial Warriors.不起眼的地衣：大自然隐藏的抗菌勇士。
Int J Mol Sci. 2025 Mar 28;26(7):3136. doi: 10.3390/ijms26073136.
8
Advancements in herbal medicine-based nanozymes for biomedical applications.用于生物医学应用的基于草药的纳米酶的进展。
Chin Med J (Engl). 2025 May 5;138(9):1037-1049. doi: 10.1097/CM9.0000000000003584. Epub 2025 Apr 1.
9
siRNA-mediated inhibition of hTERT enhances the effects of curcumin in promoting cell death in precursor-B acute lymphoblastic leukemia cells: an in silico and in vitro study.小干扰RNA介导的人端粒酶逆转录酶抑制增强姜黄素促进前体B细胞急性淋巴细胞白血病细胞死亡的作用：一项计算机模拟和体外研究
Sci Rep. 2025 Jan 24;15(1):3083. doi: 10.1038/s41598-025-85329-z.
10
Recent advances in self-targeting natural product-based nanomedicines.基于天然产物的自靶向纳米药物的最新进展。
J Nanobiotechnology. 2025 Jan 20;23(1):31. doi: 10.1186/s12951-025-03092-9.
聚乙二醇-桦木酸（PEG-BA）聚合物-药物偶联物在胰腺癌生物学模型中诱导细胞凋亡和抗氧化作用。
Polymers (Basel). 2023 Jan 14;15(2):448. doi: 10.3390/polym15020448.
4
Optimization of Gefitinib-Loaded Nanostructured Lipid Carrier as a Biomedical Tool in the Treatment of Metastatic Lung Cancer.优化载吉非替尼的纳米结构脂质载体作为治疗转移性肺癌的生物医学工具。
Molecules. 2023 Jan 3;28(1):448. doi: 10.3390/molecules28010448.
5
The Integration of Nanomedicine with Traditional Chinese Medicine: Drug Delivery of Natural Products and Other Opportunities.纳米医学与传统中医的整合：天然产物的药物递送及其他机遇
Mol Pharm. 2023 Feb 6;20(2):886-904. doi: 10.1021/acs.molpharmaceut.2c00882. Epub 2022 Dec 23.
6
Natural Small-Molecule-Based Carrier-Free Self-Assembly Library Originated from Traditional Chinese Herbal Medicine.源自传统中草药的基于天然小分子的无载体自组装文库。
ACS Omega. 2022 Nov 20;7(48):43510-43521. doi: 10.1021/acsomega.2c04098. eCollection 2022 Dec 6.
7
Natural Carrier-Free Binary Small Molecule Self-Assembled Hydrogel Synergize Antibacterial Effects and Promote Wound Healing by Inhibiting Virulence Factors and Alleviating the Inflammatory Response.天然无载体二元小分子自组装水凝胶通过抑制毒力因子和减轻炎症反应协同发挥抗菌作用并促进伤口愈合。
Small. 2023 Feb;19(5):e2205528. doi: 10.1002/smll.202205528. Epub 2022 Nov 29.
8
Protective Effects of Piperine on Ethanol-Induced Gastric Mucosa Injury by Oxidative Stress Inhibition.胡椒碱通过抑制氧化应激对乙醇诱导的胃黏膜损伤的保护作用。
Nutrients. 2022 Nov 10;14(22):4744. doi: 10.3390/nu14224744.
9
Physical Characterization and Safety Evaluation of Folic Acid-conjugated Mesoporous Silica Nanoparticles Loaded with Rhodojaponin III.载罗通定 III 的叶酸偶联介孔硅纳米粒子的物理特性表征及安全性评价。
Curr Drug Deliv. 2023;20(10):1559-1568. doi: 10.2174/1567201820666221108121347.
10
The role of berberine in Covid-19: potential adjunct therapy.小檗碱在新冠病毒肺炎中的作用：一种潜在的辅助治疗方法。
Inflammopharmacology. 2022 Dec;30(6):2003-2016. doi: 10.1007/s10787-022-01080-1. Epub 2022 Oct 2.