Department of Hematology and Hematology Research Laboratory, West China Hospital, Sichuan University, Chengdu, PR China.
Department of Hematology and Hematology Research Laboratory, West China Hospital, Sichuan University, Chengdu, PR China.
Cytokine. 2020 Jan;125:154820. doi: 10.1016/j.cyto.2019.154820. Epub 2019 Sep 4.
The association of the IL-10 gene polymorphism with immune thrombocytopenic purpura (ITP, also called idiopathic thrombocytopenic purpura) susceptibility has been investigated in several studies; however, the association remains controversial. The present meta-analysis aimed to determine whether the IL-10 (-1082) polymorphism is associated with an increased risk of ITP.
Eligible articles were searched in EMBASE, PubMed, CNKI, WanFang, and HuGE Navigator, without any restriction of publication language. The odds ratios (ORs) and 95% confidence intervals (CIs) were used to identify any potential associations between the IL-10 (-1082 A/G) polymorphism and the risk of ITP.
This meta-analysis included six eligible studies with 384 cases and 409 controls. There was no significant association between the IL-10 (-1082) polymorphism and the risk of ITP in any of the genetic models. Three subgroups were stratified according to population ethnicity, disease subtype (acute or chronic), and age (child or adult). No statistically significant differences were observed in age and ethnicity between cases and controls. However, subtype analysis indicated significant associations for acute ITP in the allele model (OR = 1.76, 95% CI = [1.07; 2,89]), the recessive model (OR = 2.66, 95% CI = [1.17; 6.07]), and the homozygote model (OR = 2.65, 95% CI = [1.07; 6.55]).
There is scarce evidence to confirm an association between the IL-10 (-1082) polymorphism and the risk of ITP. However, the IL-10 (-1082) polymorphism might be associated with the risk of acute ITP. Additional large, well-designed epidemiological studies should be performed to draw definitive conclusions.
白细胞介素 10（IL-10）基因多态性与免疫性血小板减少性紫癜（ITP，也称为特发性血小板减少性紫癜）易感性的相关性已在多项研究中进行了探讨；然而，其相关性仍存在争议。本荟萃分析旨在确定 IL-10（-1082）多态性是否与 ITP 的发病风险增加相关。
在 EMBASE、PubMed、CNKI、万方和 HuGE Navigator 中检索符合条件的文献，对发表语言不设限制。使用比值比（OR）和 95%置信区间（CI）来确定 IL-10（-1082A/G）多态性与 ITP 风险之间的任何潜在关联。
本荟萃分析纳入了 6 项符合条件的研究，共纳入 384 例病例和 409 例对照。在任何遗传模型中，IL-10（-1082）多态性与 ITP 的发病风险均无显著相关性。根据人群种族、疾病亚型（急性或慢性）和年龄（儿童或成人）对三个亚组进行分层。病例和对照之间在年龄和种族方面无统计学差异。然而，亚型分析表明，在等位基因模型（OR=1.76，95%CI=[1.07；2,89]）、隐性模型（OR=2.66，95%CI=[1.17；6.07]）和纯合子模型（OR=2.65，95%CI=[1.07；6.55]）中，急性 ITP 与 IL-10（-1082）多态性显著相关。
目前证据尚不足以证实 IL-10（-1082）多态性与 ITP 的发病风险相关。然而，IL-10（-1082）多态性可能与急性 ITP 的发病风险相关。需要开展更多设计良好的大型流行病学研究，以得出明确的结论。
