Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, Section of Psychiatry, University of Genoa, Genoa, Italy; IRCCS Ospedale Policlinico San Martino, Genoa, Italy.
Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest, Hungary; MTA-SE Neuropsychopharmacology and Neurochemistry Research Group, Hungarian Academy of Sciences, Semmelweis University, Budapest, Hungary; NAP-2-SE New Antidepressant Target Research Group, Semmelweis University, Budapest, Hungary.
Psychiatry Res. 2019 Nov;281:112528. doi: 10.1016/j.psychres.2019.112528. Epub 2019 Aug 19.
Differences between BD-I and BD-II patients with regard to specific illness characteristics are poorly understood. This study is mainly aimed to compare socio-demographic and clinical characteristics between BD-I and BD-II patients with the goal of clarifying possible predictors of clinical course. The sample of this cohort study is composed of 391 currently euthymic bipolar patients. Participants were all receiving only maintenance treatment; their psychopharmacological regimens and psychopathological conditions were stable at assessment. After univariate analyses, BD-II patients were more likely to be female, had more frequently a recent depressive episode and substance abuse/dependence relative to BD-I subjects. BD-II patients were also less likely to have a positive history of psychiatric conditions in family, psychotic symptoms at first episode, and first depressive illness episode. Moreover, BD-II were older at their illness onset and first treatment than BD-I patients. Furthermore, BD-I were more likely to have higher depressive, manic, anxiety, and symptoms severity than BD-II patients. After logistic regression analyses, being female (OR = 0.289), having psychiatric conditions in family (OR = 0.273), and higher severity of illness at CGI (OR = 0.604) were all significantly associated with BD-II. Additional studies are required to replicate these results, and facilitate the prediction of BD outcomes according to the specified profile.
BD-I 型和 BD-II 型患者在特定疾病特征方面的差异尚未得到充分理解。本研究主要旨在比较 BD-I 型和 BD-II 型患者的社会人口统计学和临床特征，以期阐明可能的临床病程预测因素。本队列研究的样本由 391 名目前病情稳定的双相情感障碍患者组成。所有参与者均仅接受维持治疗；在评估时，他们的精神药理学方案和精神病理状况稳定。在单变量分析后，BD-II 型患者更有可能为女性，与 BD-I 患者相比，最近有抑郁发作和物质滥用/依赖的情况更为常见。BD-II 型患者也不太可能有阳性的家族精神病史、首发精神病症状和首发抑郁发作。此外，BD-II 型患者的发病和首次治疗年龄大于 BD-I 型患者。此外，BD-I 型患者的抑郁、躁狂、焦虑和症状严重程度均高于 BD-II 型患者。在逻辑回归分析后，女性（OR=0.289）、有家族精神病史（OR=0.273）和 CGI 严重程度较高（OR=0.604）与 BD-II 显著相关。需要进一步的研究来复制这些结果，并根据特定的特征促进对双相情感障碍结果的预测。
