Di Salvo Gabriele, Porceddu Giorgia, Albert Umberto, Maina Giuseppe, Rosso Gianluca
San Luigi Gonzaga University Hospital, Department of Neurosciences 'Rita Levi Montalcini', University of Turin, Turin, Italy.
Department of Neurosciences 'Rita Levi Montalcini', University of Turin, Turin, Italy.
Ann Gen Psychiatry. 2023 Mar 23;22(1):12. doi: 10.1186/s12991-023-00442-5.
Despite a high number of studies investigating the correlation between long Duration of Untreated Illness (DUI) and poor course of Bipolar Disorder (BD), the results concerning the impact of DUI on some specific factors, such as suicidality and medical comorbidities, are still inconsistent. This cross-sectional observational study aimed at analyzing potential socio-demographic and clinical correlates of long DUI in a large cohort of real-world, well-characterized BD patients.
The socio-demographic and clinical characteristics of 897 patients with BD were collected. The sample was divided for analysis in two groups (short DUI vs long DUI) according to a DUI cutoff of 2 years. Comparisons were performed using χ tests for categorical variables and the Kruskal-Wallis test for continuous variables. Logistic regression (LogReg) was used to identify explanatory variables associated with DUI (dependent variable).
Six-hundred and sixty patients (75.5%) presented long DUI (> 2 years) and mean DUI was 15.7 years. The LogReg analysis confirmed the association of long DUI with bipolar II disorder (p: 0.016), lower age at onset (p < 0.001), depressive predominant polarity (p: 0.018), depressive polarity onset (p < 0.001), longer duration of illness (p < 0.001), lifetime suicide attempts (p: 0.045) and current medical comorbidities (p: 0.019).
The present study confirms the association between long DUI and higher risk of suicide attempts in patients with BD. Moreover, an association between long DUI and higher rates of medical conditions has been found.
尽管有大量研究探讨未治疗疾病持续时间（DUI）与双相情感障碍（BD）病程不良之间的相关性，但关于DUI对某些特定因素（如自杀倾向和合并症）的影响结果仍不一致。这项横断面观察性研究旨在分析一大群真实世界、特征明确的BD患者中长DUI的潜在社会人口学和临床相关因素。
收集了897例BD患者的社会人口学和临床特征。根据2年的DUI临界值将样本分为两组（短DUI组与长DUI组）进行分析。对分类变量使用χ检验，对连续变量使用Kruskal-Wallis检验进行比较。使用逻辑回归（LogReg）来识别与DUI（因变量）相关的解释变量。
660例患者（75.5%）存在长DUI（>2年），平均DUI为15.7年。LogReg分析证实长DUI与双相II型障碍（p：0.016）、发病年龄较低（p<0.001）、抑郁为主极性（p：0.018）、抑郁极性发病（p<0.001）、病程较长（p<0.001）、终生自杀未遂（p：0.045）和当前合并症（p：0.019）相关。
本研究证实BD患者中长DUI与自杀未遂风险较高之间存在关联。此外，还发现长DUI与较高的医疗疾病发生率之间存在关联。
