在越南胡志明市，至少患有 5 年 2 型糖尿病的患者肾小球滤过率降低：患病率及相关因素。

Decreased glomerular filtration rate in patients with at least 5 years of type 2 diabetes in Ho Chi Minh City, Vietnam: Prevalence and associated factors.

机构信息

Faculty of Internal Medicine, Pham Ngoc Thach School of Medicine, 02 Duong Quang Trung Street, Ward 12, District 10, Ho Chi Minh City, Viet Nam.

Outpatient-Clinic of Internal Medicine, District 10 Hospital, 571 Su Van Hanh Street, Ward 13, District 10, Ho Chi Minh City, Viet Nam.

出版信息

Prim Care Diabetes. 2020 Apr;14(2):173-180. doi: 10.1016/j.pcd.2019.08.003. Epub 2019 Sep 5.

DOI:10.1016/j.pcd.2019.08.003

PMID:31494076

Abstract

AIMS

This study determined the prevalence and associated factors of decreased estimated glomerular filtration rate (eGFR) in patients who had type 2 diabetes for at least 5 years.

METHODS

A cohort study was conducted in 467 outpatients in a community-based hospital in Ho Chi Minh City, Vietnam. Serum creatinine were tested twice, at two occasions at least 3 months apart. The confirmatory eGFR was the average of the two eGFR of which the difference was ≤20%. The mean urine albumin-to-creatinine ratio was calculated from two consecutive early morning specimens.

RESULTS

Most patients were female with a mean age of 61.7 (8.0) years. Albuminuria was found in 40% of participants, and the prevalence of decreased eGFR was 7.5% (n=35). Individuals with declined eGFR were older (p<0.001), had duration of diabetes longer (p=0.025), higher systolic blood pressure (p=0.010) and higher acid uric level (p<0.001), increased albumin excretion (p=0.009), and more proliferative retinopathy (p=0.011) than those with non-declined eGFR.

CONCLUSIONS

Although decreased eGFR in type 2 diabetes patients was not prevalent, the strategies to prevent the progressive decline of GFR should be done to prevent patients from progressing to advanced renal disease.

摘要

目的

本研究旨在确定至少患有 5 年 2 型糖尿病的患者估算肾小球滤过率（eGFR）下降的患病率及其相关因素。

方法

在越南胡志明市的一家社区医院对 467 名门诊患者进行了一项队列研究。两次检测血清肌酐，两次检测至少相隔 3 个月。确认的 eGFR 是两次 eGFR 的平均值，两次 eGFR 的差值≤20%。平均尿白蛋白/肌酐比值由两个连续的晨尿标本计算得出。

结果

大多数患者为女性，平均年龄为 61.7（8.0）岁。40%的参与者存在蛋白尿，eGFR 下降的患病率为 7.5%（n=35）。eGFR 下降的个体年龄较大（p<0.001），糖尿病病程较长（p=0.025），收缩压较高（p=0.010）和尿酸水平较高（p<0.001），白蛋白排泄增加（p=0.009），且增殖性视网膜病变（p=0.011）更为常见。