Queen Mary, the University of London, Medical College of Nanchang University, Nanchang 330006, PR China.
Department of Physiology, Medical College of Nanchang University, Nanchang 330006, PR China.
Pharmacol Biochem Behav. 2019 Nov;186:172788. doi: 10.1016/j.pbb.2019.172788. Epub 2019 Sep 5.
This review summarizes and evaluates the relationship between neuropathic pain and P2Y receptors from inception to 2019. Purinergic receptors have been well studied in recent years using various molecular biological methods. The main research objective of this review is to determine the association of P2Y1, P2Y2, P2Y6, P2Y12 and P2Y13 receptors with neuropathic pain. This review includes the most comprehensive subtypes of P2Y that related to neuropathic pain and the current therapeutic method of neuropathic pain. G protein-coupled P2Y receptors are located on neurons, astrocytes, oligodendrocytes and microglial cells and regulate neurotransmission. Nerve injury is the prime reason for abnormal regulation of P2Y receptor mRNA expression, subsequently, inducing neuropathic pain. Neuropathic pain is a type of chronic pain that is divided into peripheral, central and mixed. Numerous studies demonstrated a positive correlation between the expression level of P2Y receptors and neuropathic pain generation. Also, several reports showed that P2Y short hairpin RNA (shRNA) and P2Y antagonist can be used as an analgesic to relieve neuropathic pain via decreasing P2Y receptor expression level and neural cell activation. However, the transformation process from basic experiments to clinical applications is a long process. Current deficiencies and future research directions are discussed at the end of this review.
这篇综述总结和评估了从 2019 年以前神经病理性疼痛与 P2Y 受体的关系。近年来，已经使用各种分子生物学方法对嘌呤能受体进行了很好的研究。本篇综述的主要研究目的是确定 P2Y1、P2Y2、P2Y6、P2Y12 和 P2Y13 受体与神经病理性疼痛的关系。本篇综述包括与神经病理性疼痛相关的最全面的 P2Y 亚型以及目前治疗神经病理性疼痛的方法。G 蛋白偶联 P2Y 受体位于神经元、星形胶质细胞、少突胶质细胞和小胶质细胞上，调节神经递质的传递。神经损伤是 P2Y 受体 mRNA 表达异常调节的主要原因，进而导致神经病理性疼痛。神经病理性疼痛是一种慢性疼痛，分为周围性、中枢性和混合性。大量研究表明，P2Y 受体的表达水平与神经病理性疼痛的发生呈正相关。此外，一些报道表明，P2Y 短发夹 RNA（shRNA）和 P2Y 拮抗剂可以通过降低 P2Y 受体表达水平和神经细胞激活来用作镇痛剂，以缓解神经病理性疼痛。然而，从基础实验到临床应用的转化过程是一个漫长的过程。在这篇综述的最后讨论了当前的不足和未来的研究方向。
