Department of Internal Medicine, University Hospital Marqués de Valdecilla, University of Cantabria, IDIVAL, Santander, Spain.
Galgo Medical, Barcelona, Spain.
Arch Osteoporos. 2019 Sep 7;14(1):98. doi: 10.1007/s11657-019-0645-7.
We analyzed volumetric bone mineral density, by 3D analysis, in 76 people with Down syndrome and 76 controls. People with Down syndrome, particularly men, have a lower hip volumetric bone mineral density than the general population. Besides, volumetric bone mineral density declines more rapidly in Down syndrome.
People with Down syndrome (DS) have a lower areal bone mineral density (aBMD) estimated by dual-energy X-ray absorptiometry (DXA). However, they have smaller-sized bones, which could influence the measurements. Therefore, our objective was to determine volumetric BMD in these patients.
We included 76 outpatients with DS and 76 control healthy volunteers matched for age and sex distribution. Clinical data were obtained with a standardized interview and physical exam, including age, sex, height, weight, and body mass index (BMI). aBMD was measured by dual-energy X-ray at the femoral neck (FN) and total hip (TH). The 3D-SHAPER® software (version 2.8, Galgo Medical, Barcelona, Spain) was used to derive 3D analysis from participants' hip DXA scans.
DS femurs had a similar 3D geometry, compared with the femurs of controls. However, 3D analysis showed that participants with DS had smaller cortical thickness (1.84 mm ± 0.17 vs. 2.02 ± 0.20 mm; p < 0.0001), cortical vBMD (777 ± 49 mg/cm vs. 809 ± 43 mg/cm; p < 0.0001), and cortical sBMD (143 ± 19 mg/cm vs. 164 ± 22 mg/cm; p < 0.0001). After adjustment for age and BMI, all 3D measurements remained lower in DS than in controls. These differences were more marked in men than in women. vBMD decreased with age in controls and DS, but the decline was greater in DS for all 3D parameters.
People with DS, particularly men, have a lower hip vBMD than the general population. Besides, vBMD declines more rapidly in DS.
我们通过 3D 分析，对 76 名唐氏综合征患者和 76 名对照者的容积骨密度进行了分析。唐氏综合征患者（尤其是男性）的髋部容积骨密度低于普通人群。此外，唐氏综合征患者的容积骨密度下降速度更快。
通过双能 X 射线吸收法（DXA）测定，唐氏综合征患者的骨矿物质密度（aBMD）低于正常人群。然而，他们的骨骼较小，这可能会影响测量结果。因此，我们的目的是确定这些患者的容积 BMD。
我们纳入了 76 名唐氏综合征门诊患者和 76 名年龄和性别相匹配的健康志愿者作为对照组。通过标准化访谈和体格检查获得临床数据，包括年龄、性别、身高、体重和体重指数（BMI）。使用双能 X 射线在股骨颈（FN）和全髋（TH）处测量 aBMD。使用 3D-SHAPER®软件（Galgo Medical，巴塞罗那，西班牙，版本 2.8）对参与者的髋部 DXA 扫描进行 3D 分析。
与对照组相比，唐氏综合征患者的股骨具有相似的 3D 几何形状。然而，3D 分析显示，唐氏综合征患者的皮质厚度较小（1.84 ± 0.17 毫米 vs. 2.02 ± 0.20 毫米；p < 0.0001），皮质 vBMD（777 ± 49 毫克/立方厘米 vs. 809 ± 43 毫克/立方厘米；p < 0.0001）和皮质 sBMD（143 ± 19 毫克/立方厘米 vs. 164 ± 22 毫克/立方厘米；p < 0.0001）。在调整年龄和 BMI 后，所有 3D 测量结果在唐氏综合征患者中仍低于对照组。在男性中，这些差异比在女性中更为明显。在对照组和唐氏综合征患者中，vBMD 随年龄增长而下降，但在所有 3D 参数中，唐氏综合征患者的下降速度更快。
唐氏综合征患者（尤其是男性）的髋部容积骨密度低于普通人群。此外，唐氏综合征患者的容积骨密度下降速度更快。
