Division of Cardiovascular Health and Disease, Department of Internal Medicine, Heart, Lung and Vascular Institute, University of Cincinnati, Cincinnati, OH, 45267, USA.
J Muscle Res Cell Motil. 2020 Dec;41(4):341-353. doi: 10.1007/s10974-019-09553-7. Epub 2019 Sep 7.
Skeletal muscle, the essential organ for locomotion, as well as energy reservoir and expenditure, has robust regenerative capacity in response to mechanical stress and injury. As muscle-specific stem cells, satellite cells are responsible for providing new myoblasts during the process of muscle growth and regeneration. Self-renewal capacity and the fate of satellite cells are highly regulated and influenced by their surrounding factors, such as extracellular matrix and soluble proteins. The strong myogenic potential of satellite cells makes them a potential resource for stem cell therapy to cure genetic muscle disease and repair injured muscle. Here, we both review key features of satellite cells during skeletal muscle development and regeneration and summarize recent outcomes of satellite cell transplantation studies.
骨骼肌是运动的必需器官，也是能量的储存库和消耗器官，它具有强大的再生能力，能够对机械应激和损伤做出反应。作为肌肉特异性干细胞，卫星细胞负责在肌肉生长和再生过程中提供新的成肌细胞。卫星细胞的自我更新能力和命运受到其周围因素的高度调控和影响，如细胞外基质和可溶性蛋白。卫星细胞强大的成肌潜能使其成为一种潜在的干细胞治疗资源，可用于治疗遗传性肌肉疾病和修复受损肌肉。在这里，我们既回顾了卫星细胞在骨骼肌发育和再生过程中的关键特征，也总结了卫星细胞移植研究的最新成果。
