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Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer's Disease.阿他贝司他在临床前阿尔茨海默病试验中的初步结果。
N Engl J Med. 2019 Apr 11;380(15):1483-1485. doi: 10.1056/NEJMc1813435.
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Randomized Trial of Verubecestat for Prodromal Alzheimer's Disease.随机试验：维鲁贝司他治疗前驱阿尔茨海默病。
N Engl J Med. 2019 Apr 11;380(15):1408-1420. doi: 10.1056/NEJMoa1812840.
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A critical appraisal of amyloid-β-targeting therapies for Alzheimer disease.阿尔茨海默病淀粉样蛋白-β靶向治疗的评价。
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Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease.遗传性阿尔茨海默病的纵向认知和生物标志物变化。
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Clinical Research on Alzheimer's Disease: Progress and Perspectives.阿尔茨海默病的临床研究：进展与展望。
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Biochemically-defined pools of amyloid-β in sporadic Alzheimer's disease: correlation with amyloid PET.散发性阿尔茨海默病中生物化学定义的淀粉样蛋白-β池：与淀粉样蛋白 PET 的相关性。
Brain. 2017 May 1;140(5):1486-1498. doi: 10.1093/brain/awx057.
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The amyloid hypothesis of Alzheimer's disease at 25 years.阿尔茨海默病淀粉样蛋白假说25年回顾
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Perspectives on the Tertiary Prevention Strategy for Alzheimer's Disease.阿尔茨海默病三级预防策略的观点
Curr Alzheimer Res. 2016;13(3):307-16. doi: 10.2174/1567205013666151215110114.
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η-Secretase processing of APP inhibits neuronal activity in the hippocampus.APP的η-分泌酶加工过程会抑制海马体中的神经元活动。
Nature. 2015 Oct 15;526(7573):443-7. doi: 10.1038/nature14864. Epub 2015 Aug 31.
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A mutation in APP protects against Alzheimer's disease and age-related cognitive decline.APP 中的一个突变可预防阿尔茨海默病和与年龄相关的认知能力下降。
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Early Intervention in Alzheimer's Disease: How Early is Early Enough?

作者信息

Fan Dong-Yu, Wang Yan-Jiang

机构信息

Department of Neurology and Center for Clinical Neuroscience, Daping Hospital, Third Military Medical University, Chongqing, 400042, China.

Chongqing Key Laboratory of Aging and Brain Diseases, Chongqing, 400042, China.

出版信息

Neurosci Bull. 2020 Feb;36(2):195-197. doi: 10.1007/s12264-019-00429-x. Epub 2019 Sep 7.

DOI:10.1007/s12264-019-00429-x
PMID:31494835
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6977799/
Abstract
摘要