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心血管病床与心血管病医生人数之比与急性心力衰竭患者院内死亡率:日本全国研究

Number of Cardiologists per Cardiovascular Beds and In-Hospital Mortality for Acute Heart Failure: A Nationwide Study in Japan.

机构信息

Department of Cardiovascular Medicine Nara Medical University Nara Japan.

National Cerebral and Cardiovascular Center Suita Japan.

出版信息

J Am Heart Assoc. 2019 Sep 17;8(18):e012282. doi: 10.1161/JAHA.119.012282. Epub 2019 Sep 9.

Abstract

Background Little evidence is available about the number of cardiologists required for appropriate treatment of heart failure (HF). Our objective was to determine the association between the number of cardiologists per cardiology beds for treating patients with acute HF and in-hospital mortality. Methods and Results This was a cross-sectional study, and we used the Japanese Registry of All Cardiac and Vascular Diseases Diagnosis Procedure Combination discharge database. The data of patients with HF on emergency admission from April 1, 2012, to March 31, 2014, were extracted. The patients were categorized into 4 groups by the quartiles of the numbers of cardiologists per 50 cardiovascular beds (first group: median, 4.4 [interquartile range, 3.5-5.0]; second group: median, 6.7 [interquartile range, 6.5-7.5]; third group: median, 9.7 [interquartile range, 8.8-10.1]; and fourth group: median, 16.7 [interquartile range, 14.0-23.8]). Using multilevel mixed-effect logistics regression, we determined adjusted odds ratios for in-hospital mortality. We identified 154 290 patients with HF on emergency admissions. There were 29 626, 36 587, 46 451, and 41 626 patients in the first, second, third, and fourth groups, respectively. HF severity, on the basis of New York Heart Association classification, was similar in the 3 groups. Adjusted odds ratios (95% CIs) for in-hospital mortality were 0.92 (0.82-1.04; P=0.20), 0.82 (0.72-0.92; P<0.001), and 0.70 (0.61-0.80; P<0.001) for the second, third, and fourth groups, respectively. The proportion of medication used, including angiotensin-converting enzyme inhibitors or angiotensin receptor blockers, β blockers, and mineralocorticoid receptor antagonists, was positively correlated to the number of cardiologists. Conclusions Patients hospitalized for HF in hospitals with larger numbers of cardiologists per cardiovascular beds had lower 30-day mortality.

摘要

背景

心力衰竭(HF)的适当治疗需要多少心脏病专家,目前相关证据有限。我们的目的是确定每 50 张心血管病床配备的心脏病专家数量与急性 HF 患者住院死亡率之间的关联。

方法和结果

这是一项横断面研究,我们使用了日本所有心血管疾病诊断程序组合出院数据库。从 2012 年 4 月 1 日至 2014 年 3 月 31 日,提取了因 HF 急症入院患者的数据。根据每 50 张心血管病床的心脏病专家数量的四分位数,将患者分为 4 组(第 1 组:中位数 4.4 [四分位距 3.5-5.0];第 2 组:中位数 6.7 [四分位距 6.5-7.5];第 3 组:中位数 9.7 [四分位距 8.8-10.1];第 4 组:中位数 16.7 [四分位距 14.0-23.8])。使用多级混合效应逻辑回归,我们确定了住院死亡率的调整后比值比。我们确定了 154290 名因 HF 急症入院的患者。第 1、2、3 和第 4 组分别有 29626、36587、46451 和 41626 名患者。根据纽约心脏协会(NYHA)分类,HF 严重程度在 3 组之间相似。调整后比值比(95%CI)分别为 0.92(0.82-1.04;P=0.20)、0.82(0.72-0.92;P<0.001)和 0.70(0.61-0.80;P<0.001)。使用的药物比例(包括血管紧张素转换酶抑制剂或血管紧张素受体阻滞剂、β受体阻滞剂和盐皮质激素受体拮抗剂)与心脏病专家数量呈正相关。

结论

在每 50 张心血管病床配备较多心脏病专家的医院住院治疗的 HF 患者,30 天死亡率较低。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/31be/6818015/9b315657af2b/JAH3-8-e012282-g001.jpg

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