Max Planck Institute for Biology of Ageing, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
Max Planck Institute for Biology of Ageing, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany; Center for Molecular Medicine, University of Cologne, Cologne, Germany.
Trends Cell Biol. 2019 Nov;29(11):888-900. doi: 10.1016/j.tcb.2019.08.003. Epub 2019 Sep 5.
Mitochondrial morphology is a crucial determinant of mitochondrial and cellular function. Opposing fusion and fission events shape the tubular mitochondrial reticulum and ensure mitochondrial transport within cells. Cellular stress and pathophysiological conditions can lead to fragmentation of the mitochondrial network, which facilitates mitophagy and is associated with cell death. However, mitochondrial shape changes are also intertwined with the cellular metabolism, and metabolic switches can induce but also result from alterations in mitochondrial morphology. Here, we discuss recent advances in the field of mitochondrial dynamics, demonstrating cell- and tissue-specific effects of mitochondrial fragmentation on cellular metabolism, cell survival, and mitochondrial quality control.
线粒体形态是线粒体和细胞功能的一个关键决定因素。相反的融合和分裂事件塑造了管状的线粒体网络，并确保了线粒体在细胞内的运输。细胞应激和病理生理条件可导致线粒体网络的碎片化，这有利于细胞自噬，并与细胞死亡相关。然而，线粒体形状的变化也与细胞代谢交织在一起，代谢转换可以诱导，也可以导致线粒体形态的改变。在这里，我们讨论了线粒体动力学领域的最新进展，展示了线粒体碎片化对细胞代谢、细胞存活和线粒体质量控制的细胞和组织特异性影响。
