Global Research Laboratory, School of Biological Sciences, Seoul National University, Seoul 08826, Korea.
Mol Cells. 2018 Jan 31;41(1):18-26. doi: 10.14348/molcells.2018.2277. Epub 2018 Jan 23.
Mitochondrial quality control systems are essential for the maintenance of functional mitochondria. At the organelle level, they include mitochondrial biogenesis, fusion and fission, to compensate for mitochondrial function, and mitophagy, for degrading damaged mitochondria. Specifically, in mitophagy, the target mitochondria are recognized by the autophagosomes and delivered to the lysosome for degradation. In this review, we describe the mechanisms of mitophagy and the factors that play an important role in this process. In particular, we focus on the roles of mitophagy adapters and receptors in the recognition of damaged mitochondria by autophagosomes. In addition, we also address a functional association of mitophagy with mitochondrial dynamics through the interaction of mitophagy adaptor and receptor proteins with mitochondrial fusion and fission proteins.
线粒体质量控制系统对于维持功能正常的线粒体至关重要。在细胞器层面，线粒体生物发生、融合和裂变等过程可以补偿线粒体功能，而自噬则可以降解受损的线粒体。具体来说，在自噬中，自噬体识别靶向线粒体，并将其递送至溶酶体进行降解。在这篇综述中，我们描述了自噬的机制以及在这个过程中发挥重要作用的因素。特别地，我们关注自噬体识别受损线粒体的过程中自噬衔接蛋白和受体的作用。此外，我们还讨论了自噬与线粒体动力学之间的功能关联，即自噬衔接蛋白和受体蛋白与线粒体融合和裂变蛋白的相互作用。
