Magdoud O, Souissi A, Chelly I, Haouet S, Mokni M
Dermatology department, La Rabta Hospital, Tunis, Tunisia.
Dermatology department, La Rabta Hospital, Tunis, Tunisia.
Rev Med Interne. 2020 Jan;41(1):54-57. doi: 10.1016/j.revmed.2019.08.001. Epub 2019 Sep 5.
Pyoderma gangrenosum (PG) is a neutrophilic dermatosis that is traditionally associated with systemic disorders such as chronic inflammatory bowel diseases, rheumatoid arthritis and malignant hematologic disorders. Its association with systemic lupus erythematosus (SLE) is rare and not well known. We report a case of this association with a review of the literature.
A 43-year-old female patient, followed for 4 years for SLE, presented a deep ulceration of the anterior face of the left thigh with inflammatory borders, an ulcerated nodule of the right shoulder and four small ulcerations of the back of the right hand. The biopsy of the ulceration of the left thigh concluded to PG. The patient was treated by corticosteroids with complete healing of lesions.
The prognosis of lupus does not seem to be aggravated by PG and the treatments of a SLE flare are usually enough for treating associated PG.
坏疽性脓皮病（PG）是一种嗜中性皮病，传统上与慢性炎症性肠病、类风湿性关节炎和恶性血液系统疾病等全身性疾病相关。它与系统性红斑狼疮（SLE）的关联罕见且鲜为人知。我们报告一例这种关联并对文献进行综述。
一名43岁女性患者，因SLE接受治疗4年，左大腿前侧出现一处边界有炎症的深部溃疡、右肩部一个溃疡结节以及右手背四个小溃疡。左大腿溃疡活检诊断为PG。患者接受皮质类固醇治疗后病变完全愈合。
PG似乎不会加重狼疮的预后，SLE发作的治疗通常足以治疗相关的PG。
