Niwa T, Takeda N, Tatematsu A, Matsuura S, Yoshida M, Nagatsu T
Department of Internal Medicine, Nagoya University Branch Hospital, Japan.
J Chromatogr. 1988 Oct 28;452:85-91. doi: 10.1016/s0021-9673(01)81439-4.
1,2,3,4-Tetrahydroisoquinoline (TIQ) was quantitated by use of gas chromatography-mass spectrometry in brains and livers of marmosets which showed parkinsonism after daily subcutaneous injection of TIQ. TIQ showed greatly increased levels in the brains and livers of the TIQ-treated marmosets, with no detectable metabolites of TIQ. TIQ was present as an endogenous amine in the brains and livers of saline-treated marmosets at very low concentrations. It thus seems that TIQ can pass easily through the blood-brain barrier but cannot be metabolized in the brain or the liver. It is possible that TIQ accumulated in the brain may produce parkinsonism.
在每日皮下注射1,2,3,4-四氢异喹啉（TIQ）后出现帕金森症的狨猴的大脑和肝脏中，通过气相色谱-质谱联用法定量分析了TIQ。在接受TIQ治疗的狨猴的大脑和肝脏中，TIQ水平大幅升高，且未检测到TIQ的代谢产物。在接受生理盐水治疗的狨猴的大脑和肝脏中，TIQ以极低浓度作为内源性胺存在。因此，TIQ似乎能够轻易通过血脑屏障，但无法在大脑或肝脏中代谢。大脑中积累的TIQ有可能导致帕金森症。
