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帕金森病患者及正常人脑内四氢异喹啉和2-甲基四氢喹啉的存在情况。

Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains.

作者信息

Niwa T, Takeda N, Kaneda N, Hashizume Y, Nagatsu T

出版信息

Biochem Biophys Res Commun. 1987 Apr 29;144(2):1084-9. doi: 10.1016/s0006-291x(87)80075-x.

DOI:10.1016/s0006-291x(87)80075-x
PMID:3579928
Abstract

1,2,3,4-Tetrahydroisoquinoline (TIQ) and 2-methyl-1,2,3,4-tetrahydroquinoline (2-Me-TQ) were identified for the first time by gas chromatography-mass spectrometry in the parkinsonian and normal human brains. TIQ, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was markedly increased in the parkinsonian brain and could be an endogenous neurotoxin to induce Parkinson's disease.

摘要

通过气相色谱-质谱联用技术，首次在帕金森病患者和正常人脑中鉴定出1,2,3,4-四氢异喹啉（TIQ）和2-甲基-1,2,3,4-四氢喹啉（2-Me-TQ）。TIQ是1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）的类似物，在帕金森病患者脑中显著增加，可能是一种诱发帕金森病的内源性神经毒素。

相似文献

1
Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains.帕金森病患者及正常人脑内四氢异喹啉和2-甲基四氢喹啉的存在情况。
Biochem Biophys Res Commun. 1987 Apr 29;144(2):1084-9. doi: 10.1016/s0006-291x(87)80075-x.
2
Presence of 2-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline and 1,2-dimethyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline, novel endogenous amines, in parkinsonian and normal human brains.帕金森病患者和正常人脑内新型内源性胺类物质2-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉和1,2-二甲基-6,7-二羟基-1,2,3,4-四氢异喹啉的存在情况。
Biochem Biophys Res Commun. 1991 Jun 14;177(2):603-9. doi: 10.1016/0006-291x(91)91831-v.
3
Detection of 1-phenyl-N-methyl-1,2,3,4-tetrahydroisoquinoline and 1-phenyl-1,2,3,4-tetrahydroisoquinoline in human brain by gas chromatography-tandem mass spectrometry.采用气相色谱-串联质谱法检测人脑中的1-苯基-N-甲基-1,2,3,4-四氢异喹啉和1-苯基-1,2,3,4-四氢异喹啉。
J Chromatogr B Biomed Appl. 1995 Jul 21;669(2):345-51. doi: 10.1016/0378-4347(95)00106-s.
4
Migration of tetrahydroisoquinoline, a possible parkinsonian neurotoxin, into monkey brain from blood as proved by gas chromatography-mass spectrometry.通过气相色谱 - 质谱法证实，一种可能的帕金森病神经毒素——四氢异喹啉从血液迁移至猴脑。
J Chromatogr. 1988 Oct 28;452:85-91. doi: 10.1016/s0021-9673(01)81439-4.
5
Endogenous synthesis of N-methyl-1,2,3,4-tetrahydroisoquinoline, a precursor of N-methylisoquinolinium ion, in the brains of primates with parkinsonism after systemic administration of 1,2,3,4-tetrahydroisoquinoline.在对患有帕金森症的灵长类动物全身给药1,2,3,4-四氢异喹啉后，其大脑中内源性合成N-甲基异喹啉鎓离子的前体N-甲基-1,2,3,4-四氢异喹啉。
J Chromatogr. 1990 Nov 30;533:145-51. doi: 10.1016/s0378-4347(00)82195-7.
6
Detection of tetrahydroisoquinoline in parkinsonian brain as an endogenous amine by use of gas chromatography-mass spectrometry.利用气相色谱-质谱联用技术检测帕金森病患者大脑中作为内源性胺类的四氢异喹啉。
J Chromatogr. 1989 Jul 21;491(2):397-403. doi: 10.1016/s0378-4347(00)82857-1.
7
Presence of tetrahydroisoquinoline and 1-methyl-tetrahydro-isoquinoline in foods: compounds related to Parkinson's disease.食品中四氢异喹啉和1-甲基-四氢异喹啉的存在：与帕金森病相关的化合物。
Life Sci. 1988;43(4):373-8. doi: 10.1016/0024-3205(88)90115-4.
8
1-Methyl-1,2,3,4-tetrahydroisoquinoline, decreasing in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse, prevents parkinsonism-like behavior abnormalities.1-甲基-1,2,3,4-四氢异喹啉在1-甲基-4-苯基-1,2,3,6-四氢吡啶处理的小鼠中含量降低，可预防帕金森样行为异常。
J Neurochem. 1991 Dec;57(6):1940-3. doi: 10.1111/j.1471-4159.1991.tb06407.x.
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Preventative effects of 1-methyl-1,2,3,4-tetrahydroisoquinoline derivatives (-functional group loading) on MPTP-induced parkinsonism in mice.1-甲基-1,2,3,4-四氢异喹啉衍生物（-官能团负载）对 MPTP 诱导的小鼠帕金森病的预防作用。
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10
[Tetrahydroisoquinolines in connection with Parkinson's disease].
Rinsho Shinkeigaku. 1989 Dec;29(12):1504-6.

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