帕金森病患者及正常人脑内四氢异喹啉和2-甲基四氢喹啉的存在情况。
Presence of tetrahydroisoquinoline and 2-methyl-tetrahydroquinoline in parkinsonian and normal human brains.
作者信息
Niwa T, Takeda N, Kaneda N, Hashizume Y, Nagatsu T
出版信息
Biochem Biophys Res Commun. 1987 Apr 29;144(2):1084-9. doi: 10.1016/s0006-291x(87)80075-x.
PMID:3579928
Abstract
1,2,3,4-Tetrahydroisoquinoline (TIQ) and 2-methyl-1,2,3,4-tetrahydroquinoline (2-Me-TQ) were identified for the first time by gas chromatography-mass spectrometry in the parkinsonian and normal human brains. TIQ, an analogue of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was markedly increased in the parkinsonian brain and could be an endogenous neurotoxin to induce Parkinson's disease.
摘要
通过气相色谱-质谱联用技术，首次在帕金森病患者和正常人脑中鉴定出1,2,3,4-四氢异喹啉（TIQ）和2-甲基-1,2,3,4-四氢喹啉（2-Me-TQ）。TIQ是1-甲基-4-苯基-1,2,3,6-四氢吡啶（MPTP）的类似物，在帕金森病患者脑中显著增加，可能是一种诱发帕金森病的内源性神经毒素。
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