炎症性肠病患者的胃肠动力和吸收障碍:患病率、诊断和治疗。
Gastrointestinal motility and absorptive disorders in patients with inflammatory bowel diseases: Prevalence, diagnosis and treatment.
机构信息
Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo 05403-000, Brazil.
Division of Gastroenterology, Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, United States,
出版信息
World J Gastroenterol. 2019 Aug 21;25(31):4414-4426. doi: 10.3748/wjg.v25.i31.4414.
Inflammatory bowel diseases (IBD), Crohn`s disease and ulcerative colitis, are chronic conditions associated with high morbidity and healthcare costs. The natural history of IBD is variable and marked by alternating periods of flare and remission. Even though the use of newer therapeutic targets has been associated with higher rates of mucosal healing, a great proportion of IBD patients remain symptomatic despite effective control of inflammation. These symptoms may include but not limited to abdominal pain, dyspepsia, diarrhea, urgency, fecal incontinence, constipation or bloating. In this setting, commonly there is an overlap with gastrointestinal (GI) motility and absorptive disorders. Early recognition of these conditions greatly improves patient care and may decrease the risk of mistreatment. Therefore, in this review we describe the prevalence, diagnosis and treatment of GI motility and absorptive disorders that commonly affect patients with IBD.
炎症性肠病(IBD),包括克罗恩病和溃疡性结肠炎,是与高发病率和医疗保健费用相关的慢性疾病。IBD 的自然病程是多变的,以炎症发作和缓解交替出现为特征。尽管使用更新的治疗靶点与更高的黏膜愈合率相关,但尽管炎症得到有效控制,仍有很大一部分 IBD 患者存在症状。这些症状可能包括但不限于腹痛、消化不良、腹泻、急迫感、粪便失禁、便秘或腹胀。在这种情况下,通常与胃肠道(GI)动力和吸收障碍重叠。早期识别这些情况可极大地改善患者的治疗效果,并降低治疗不当的风险。因此,在本综述中,我们描述了常见影响 IBD 患者的 GI 动力和吸收障碍的患病率、诊断和治疗。
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