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益生菌 ZW3 缓解 DSS 诱导的结肠炎并增强肠道稳态。

Probiotic ZW3 Alleviates DSS-Induced Colitis and Enhances Gut Homeostasis.

机构信息

State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China.

College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China.

出版信息

Int J Mol Sci. 2024 Jan 1;25(1):561. doi: 10.3390/ijms25010561.

DOI:10.3390/ijms25010561
PMID:38203732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10778761/
Abstract

Despite species having been extensively utilized in the food industry and biocontrol as part of probiotic preparations, limited knowledge exists regarding their impact on intestinal disorders. In this study, we investigated the effect of ZW3 (ZW3), a potential probiotic isolated from camel feces, on dextran sulfate sodium (DSS)-induced colitis. The results showed ZW3 partially mitigated body weight loss, disease activity index (DAI), colon shortening, and suppressed immune response in colitis mice, as evidenced by the reduction in the levels of the inflammatory markers IL-1β, TNF-α, and IL-6 ( < 0.05). ZW3 was found to ameliorate DSS-induced dysfunction of the colonic barrier by enhancing mucin 2 (MUC2), zonula occluden-1 (ZO-1), and occludin. Furthermore, enriched beneficial bacteria and decreased harmful bacteria revealed that ZW3 improved the imbalanced gut microbiota. Abnormally elevated uric acid levels in colitis were further normalized upon ZW3 supplementation. Overall, this study emphasized the protective effects of ZW3 in colitis mice as well as some potential applications in the management of inflammation-related diseases.

摘要

尽管某些物种已被广泛应用于食品工业和生物防治领域，作为益生菌制剂的一部分，但对于它们对肠道疾病的影响，我们的了解还很有限。在本研究中，我们研究了从骆驼粪便中分离出的潜在益生菌 ZW3 对葡聚糖硫酸钠（DSS）诱导的结肠炎的影响。结果表明，ZW3 部分减轻了结肠炎小鼠的体重减轻、疾病活动指数（DAI）、结肠缩短和免疫反应，炎症标志物 IL-1β、TNF-α 和 IL-6 的水平降低（<0.05）。ZW3 通过增强粘蛋白 2（MUC2）、紧密连接蛋白-1（ZO-1）和闭合蛋白，改善了 DSS 诱导的结肠屏障功能障碍。此外，有益细菌的富集和有害细菌的减少表明 ZW3 改善了肠道微生物群的失衡。补充 ZW3 后，结肠炎中异常升高的尿酸水平进一步恢复正常。总的来说，本研究强调了 ZW3 对结肠炎小鼠的保护作用，以及它在炎症相关疾病管理方面的一些潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f0/10778761/a3cacc369a63/ijms-25-00561-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f0/10778761/80045d28e7f1/ijms-25-00561-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f0/10778761/46b860c572c4/ijms-25-00561-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f0/10778761/1dc456c6f620/ijms-25-00561-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f0/10778761/39867eda8c51/ijms-25-00561-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f0/10778761/a3cacc369a63/ijms-25-00561-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f0/10778761/80045d28e7f1/ijms-25-00561-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f0/10778761/46b860c572c4/ijms-25-00561-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f0/10778761/1dc456c6f620/ijms-25-00561-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f0/10778761/39867eda8c51/ijms-25-00561-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/61f0/10778761/a3cacc369a63/ijms-25-00561-g005.jpg

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[3]
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[4]
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[5]
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[6]
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[7]
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本文引用的文献

[1]
Corylin ameliorates chronic ulcerative colitis via regulating the gut-brain axis and promoting 5-hydroxytryptophan production in the colon.

Phytomedicine. 2023-2

[2]
Low fish meal diet supplemented with probiotics ameliorates intestinal barrier and immunological function of the targeted modulation of gut microbes and derived secondary metabolites.

Front Immunol. 2022

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Fucoidan Ameliorated Dextran Sulfate Sodium-Induced Ulcerative Colitis by Modulating Gut Microbiota and Bile Acid Metabolism.

J Agric Food Chem. 2022-11-30

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Probiotic-Inspired Nanomedicine Restores Intestinal Homeostasis in Colitis by Regulating Redox Balance, Immune Responses, and the Gut Microbiome.

Adv Mater. 2023-1

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Role of the Gut-Brain Axis, Gut Microbial Composition, Diet, and Probiotic Intervention in Parkinson's Disease.

Microorganisms. 2022-7-29

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A Metabolism-Related Gene Prognostic Index Bridging Metabolic Signatures and Antitumor Immune Cycling in Head and Neck Squamous Cell Carcinoma.

Front Immunol. 2022-6-30

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Pharmacol Ther. 2022-9

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