Soheilipour Maryam, Chermahini Tahereh Ghasemi, Tamizifar Babak, Kassaian Nazila, Khorasani Marzieh Rahim, Adibi Peyman
Isfahan Gastroenterology and Hepatology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Nosocomial Infection Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.
Adv Biomed Res. 2024 Jul 29;13:43. doi: 10.4103/abr.abr_369_23. eCollection 2024.
Inflammatory bowel disease (IBD) is a digestive system ailment that causes significant bodily disruption. This problem may coexist with other digestive system illnesses. One of the diseases that reduces the quality of life and other disorders is functional dyspepsia (FD), the diagnosis of which is associated with unique limitations. In this study, we aim to investigate the relative frequency of FD in IBD patients and compare it with a healthy control group.
In a case-control study, we selected a group of IBD patients and healthy controls, and all participants were prepared for a diagnosis of FD symptoms using ROME IV criteria. Data were analyzed and compared using Chi-square and -test, and ≤ 0.05 was considered significant.
There were 100 IBD patients, including 91 with ulcerative colitis and 9 with Crohn's disease (mean age, 41.37 ± 13; 39 males, 61 females). Furthermore, 100 healthy control subjects (mean age, 44.23 ± 14; 38 males, 62 females) were analyzed. 10% of IBD patients met the criteria of FD, which was comparable with the controls (5, 5%) ( > 0.05). Some of the symptoms of irritable bowel syndrome (IBS) including abdominal pain ( = 0.01) and bowel movement = 0.02) were significantly higher in IBD patients than in non-IBD subjects.
The symptoms of FD were not significantly greater in IBD patients compared to the control group, while IBS symptoms were significantly higher in IBD individuals, indicating a possible overlap of Rome IV IBS and FD.
炎症性肠病（IBD）是一种会对身体造成严重干扰的消化系统疾病。该问题可能与其他消化系统疾病共存。功能性消化不良（FD）是降低生活质量的疾病之一，其诊断存在独特的局限性。在本研究中，我们旨在调查IBD患者中FD的相对发生率，并将其与健康对照组进行比较。
在一项病例对照研究中，我们选取了一组IBD患者和健康对照者，并根据罗马IV标准对所有参与者进行FD症状诊断的准备。使用卡方检验和t检验对数据进行分析和比较，P≤0.05被认为具有统计学意义。
有100例IBD患者，其中91例为溃疡性结肠炎，9例为克罗恩病（平均年龄41.37±13岁；男性39例，女性61例）。此外，对100名健康对照者（平均年龄44.23±14岁；男性38例，女性62例）进行了分析。10%的IBD患者符合FD标准，这与对照组（5%）相当（P>0.05）。IBD患者中包括腹痛（P = 0.01）和排便（P = 0.02）在内的一些肠易激综合征（IBS）症状显著高于非IBD受试者。
与对照组相比，IBD患者的FD症状没有显著增加，而IBD患者的IBS症状显著更高，这表明罗马IV型IBS和FD可能存在重叠。
