Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
Int J Nanomedicine. 2019 Aug 16;14:6539-6553. doi: 10.2147/IJN.S208489. eCollection 2019.
This paper reports on the incorporation of oleic acid (OA) within nanostructured lipid carriers (OA-NLC) to improve the anti-inflammatory effects in the presence of albumin.
NLCs produced via hot high-shear homogenization/ultrasonication were characterized in terms of particle size, zeta potential, and toxicity. We examined the effects of OA-NLC on neutrophil activities. Dermatologic therapeutic potential was also elucidated by using a murine model of leukotriene B4-induced skin inflammation.
In the presence of albumin, OA-NLC but not free OA inhibited superoxide generation and elastase release. Topical administration of OA-NLC alleviated neutrophil infiltration and severity of skin inflammation.
OA incorporated within NLC can overcome the interference of albumin, which would undermine the anti-inflammatory effects of OA. OA-NLC has potential therapeutic effects in topical ointments.
本文报道了将油酸（OA）包封于纳米结构脂质载体（OA-NLC）中，以在白蛋白存在的情况下提高抗炎效果。
通过热高剪切匀化/超声处理制备 NLC，并对其粒径、Zeta 电位和毒性进行了表征。我们研究了 OA-NLC 对中性粒细胞活性的影响。通过使用白细胞三烯 B4 诱导的皮肤炎症的小鼠模型，阐明了其在皮肤病治疗方面的潜力。
在白蛋白存在的情况下，OA-NLC 而非游离 OA 抑制了超氧化物的产生和弹性蛋白酶的释放。OA-NLC 的局部给药减轻了中性粒细胞浸润和皮肤炎症的严重程度。
包封于 NLC 中的 OA 可以克服白蛋白的干扰，这会削弱 OA 的抗炎作用。OA-NLC 具有在局部软膏中的治疗潜力。
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