载油酸的纳米结构脂质载体在白蛋白存在的情况下抑制中性粒细胞的活性，并减轻皮肤炎症。
Oleic acid-loaded nanostructured lipid carrier inhibit neutrophil activities in the presence of albumin and alleviates skin inflammation.
机构信息
Graduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Department of Anesthesiology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan.
出版信息
Int J Nanomedicine. 2019 Aug 16;14:6539-6553. doi: 10.2147/IJN.S208489. eCollection 2019.
AIM
This paper reports on the incorporation of oleic acid (OA) within nanostructured lipid carriers (OA-NLC) to improve the anti-inflammatory effects in the presence of albumin.
MATERIALS AND METHODS
NLCs produced via hot high-shear homogenization/ultrasonication were characterized in terms of particle size, zeta potential, and toxicity. We examined the effects of OA-NLC on neutrophil activities. Dermatologic therapeutic potential was also elucidated by using a murine model of leukotriene B4-induced skin inflammation.
RESULTS
In the presence of albumin, OA-NLC but not free OA inhibited superoxide generation and elastase release. Topical administration of OA-NLC alleviated neutrophil infiltration and severity of skin inflammation.
CONCLUSION
OA incorporated within NLC can overcome the interference of albumin, which would undermine the anti-inflammatory effects of OA. OA-NLC has potential therapeutic effects in topical ointments.
目的
本文报道了将油酸（OA）包封于纳米结构脂质载体（OA-NLC）中，以在白蛋白存在的情况下提高抗炎效果。
材料和方法
通过热高剪切匀化/超声处理制备 NLC，并对其粒径、Zeta 电位和毒性进行了表征。我们研究了 OA-NLC 对中性粒细胞活性的影响。通过使用白细胞三烯 B4 诱导的皮肤炎症的小鼠模型，阐明了其在皮肤病治疗方面的潜力。
结果
在白蛋白存在的情况下，OA-NLC 而非游离 OA 抑制了超氧化物的产生和弹性蛋白酶的释放。OA-NLC 的局部给药减轻了中性粒细胞浸润和皮肤炎症的严重程度。
结论
包封于 NLC 中的 OA 可以克服白蛋白的干扰，这会削弱 OA 的抗炎作用。OA-NLC 具有在局部软膏中的治疗潜力。
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