CFP1和14-3-3表达对胃癌的生存分析及致癌作用
The survival analysis and oncogenic effects of CFP1 and 14-3-3 expression on gastric cancer.
作者信息
Sun Jingyue, Long Yao, Peng Xin, Xiao Desheng, Zhou Jianhua, Tao Yongguang, Liu Shuang
机构信息
1Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Department of Pathology, Xiangya Hospital, Central South University, Hunan, 410078 China.
2NHC Key Laboratory of Carcinogenesis of Ministry of Health (Central South University), Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, 410078 Hunan China.
出版信息
Cancer Cell Int. 2019 Aug 31;19:225. doi: 10.1186/s12935-019-0946-3. eCollection 2019.
BACKGROUND & AIM: Gastric cancer (GC) is the third-leading cause of cancer-related deaths. We established a prospective database of patients with GC who underwent surgical treatment. In this study, we explored the prognostic significance of the expression of CFP1 and 14-3-3 in gastric cancer, by studying the specimens collected from clinical subjects.
MATERIALS & METHODS: Immunohistochemistry was used to detect the expression of CFP1 and 14-3-3 in 84 GC subjects, including 73 patients who have undergone radical gastrectomy and 11 patients who have not undergone radical surgery. Survival analysis was performed by km-plot data.
RESULTS
According to the survival analysis, we can see that the survival time of patients with high expression of CFP1 is lower than the patients with low expression in gastric cancer, while the effect of 14-3-3 is just the opposite. The survival time of patients with higher expression of 14-3-3 is also longer.
CONCLUSION
The CFP1 and 14-3-3 genes can be used as prognostic markers in patients with GC, but the study is still needed to confirm.
背景与目的
胃癌（GC）是癌症相关死亡的第三大原因。我们建立了一个接受手术治疗的胃癌患者前瞻性数据库。在本研究中，我们通过研究从临床受试者收集的标本，探讨了CFP1和14-3-3在胃癌中表达的预后意义。
材料与方法
采用免疫组织化学法检测84例GC患者中CFP1和14-3-3的表达，其中73例患者接受了根治性胃切除术，11例患者未接受根治性手术。通过km-plot数据进行生存分析。
结果
根据生存分析，我们可以看到，CFP1高表达患者在胃癌中的生存时间低于低表达患者，而14-3-3的影响则相反。14-3-3高表达患者的生存时间也更长。
结论
CFP1和14-3-3基因可作为GC患者的预后标志物，但仍需进一步研究证实。
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