Liang Wei-Tian, Liu Xiao-Fang, Huang Hai-Bo, Gao Zi-Ming, Li Kai
Department of Surgical Oncology, the First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China.
World J Gastrointest Oncol. 2020 Oct 15;12(10):1104-1118. doi: 10.4251/wjgo.v12.i10.1104.
Kinesin super family 23 (KIF23) is a member of the KIF family, and it plays an important role in mitosis and cytokinesis. Loss of expression can cause mitotic arrest. The Oncomine database is one of the largest oncogene chip databases in the world, and is an integrated data mining platform for cancer gene information. By querying the database, differences in expression between tumor tissue and normal tissue can be determined.
To study the expression and prognostic significance of KIF23 in gastric cancer (GC).
We used immunohistochemistry to compare the expression of KIF23 in GC and normal gastric tissues. We mined the data on the expression and prognosis of KIF23 in GC using Oncomine and Kaplan-Meier plotter database.
Compared with normal gastric tissues, KIF23 expression was increased in GC tissues, and correlated with T, N, and tumor-node-metastasis stages. Survival analysis showed that patients with high expression of KIF23 had a poor overall survival. There were five studies in the Oncomine database in which expression of KIF23 was significantly higher in GC tissues than in normal gastric tissues ( < 0.05). Kaplan-Meier plotter database analysis showed that recurrence-free survival, overall survival, distant metastasis free survival, and post progression survival of patients with high expression of KIF23 were lower than those of patients with low expression. Further stratified analysis found that prognostic survival indicators worsened in patients with T2 and T3 poorly differentiated adenocarcinoma with high expression of KIF23.
KIF23 is highly expressed in GC and is associated with a poor prognosis of patients. It may be of great significance in the diagnosis, treatment, and prognostic evaluation of GC.
驱动蛋白超家族23（KIF23）是KIF家族的成员之一，在有丝分裂和胞质分裂中发挥重要作用。表达缺失可导致有丝分裂停滞。Oncomine数据库是世界上最大的癌基因芯片数据库之一，是一个用于癌症基因信息的综合数据挖掘平台。通过查询该数据库，可以确定肿瘤组织与正常组织之间的表达差异。
研究KIF23在胃癌（GC）中的表达及预后意义。
我们采用免疫组织化学方法比较KIF23在GC组织和正常胃组织中的表达。我们使用Oncomine和Kaplan-Meier plotter数据库挖掘GC中KIF23的表达和预后数据。
与正常胃组织相比，KIF23在GC组织中的表达增加，且与T、N和肿瘤-淋巴结-转移分期相关。生存分析显示，KIF23高表达的患者总生存期较差。Oncomine数据库中有五项研究表明，GC组织中KIF23的表达显著高于正常胃组织（<0.05）。Kaplan-Meier plotter数据库分析显示，KIF23高表达患者的无复发生存期、总生存期、无远处转移生存期和进展后生存期均低于低表达患者。进一步的分层分析发现，KIF23高表达的T2和T3低分化腺癌患者的预后生存指标恶化。
KIF23在GC中高表达，与患者预后不良相关。它可能在GC的诊断、治疗和预后评估中具有重要意义。
