Zhao Liang, Wang Meng, Li Jun, Bi Ye, Li Minglong, Yang Jie
Department of Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.
The Second Department of Endocrinology, The Central Hospital of Taian, Taian, China.
Int J Endocrinol Metab. 2019 Jun 19;17(3):e85413. doi: 10.5812/ijem.85413. eCollection 2019 Jul.
Recently, the relationship between branched-chain amino acids (BCAAs) and diabetes mellitus (DM) has attracted worldwide attention. However, the results related to plasma BCAAs concentrations and gestational diabetes mellitus (GDM) lack statistical power due to the small sample size of a single article.
This study quantitatively summarized current observational studies to evaluate the association between plasma BCAAs concentration levels and GDM.
A systematic search was performed to select eligible publications using PubMed and EMBASE databases until July 23, 2018. The references of relevant articles were also manually searched. The quality evaluation of included studies was according to the guidelines of the Newcastle-Ottawa Scale (NOS). Data were analyzed with Review Manager 5.3 and STATA 14.0 software. In total, seven articles (including eight studies) involving 432 subjects were included.
The results showed that all three-individual plasma BCAAs concentration levels in the GDM group were higher than those in the control group (leucine: SMD = 3.76, 95% CI: 1.70 - 5.82, P (SMD) < 0.001; isoleucine: SMD = 3.15, 95% CI: 1.42 - 4.87, P (SMD) < 0.001; valine: SMD = 2.77, 95% CI: 1.21 - 4.32, P (SMD) = 0.001), and the differences were statistically significant. In addition, subgroup analysis indicated that age, body mass index (BMI), publication year, and ethnicity were positively associated with plasma BCAAs concentrations in GDM.
Plasma BCAAs, as potential biomarkers, might be associated with GDM risk, which provides useful information for the prevention and early diagnosis of GDM.
最近，支链氨基酸（BCAAs）与糖尿病（DM）之间的关系已引起全球关注。然而，由于单篇文章样本量较小，与血浆BCAAs浓度和妊娠期糖尿病（GDM）相关的结果缺乏统计学效力。
本研究定量总结当前的观察性研究，以评估血浆BCAAs浓度水平与GDM之间的关联。
使用PubMed和EMBASE数据库进行系统检索，以选择符合条件的出版物，检索截至2018年7月23日。还手动检索了相关文章的参考文献。纳入研究的质量评估依据纽卡斯尔-渥太华量表（NOS）指南。使用Review Manager 5.3和STATA 14.0软件进行数据分析。总共纳入了7篇文章（包括8项研究），涉及432名受试者。
结果显示，GDM组中所有三种个体血浆BCAAs浓度水平均高于对照组（亮氨酸：标准化均数差（SMD）= 3.76，95%置信区间（CI）：1.70 - 5.82，P（SMD）< 0.001；异亮氨酸：SMD = 3.15，95% CI：1.42 - 4.87，P（SMD）< 0.001；缬氨酸：SMD = 2.77，95% CI：1.21 - 4.32，P（SMD）= 0.001），差异具有统计学意义。此外，亚组分析表明，年龄、体重指数（BMI）、发表年份和种族与GDM患者血浆BCAAs浓度呈正相关。
血浆BCAAs作为潜在的生物标志物，可能与GDM风险相关，这为GDM的预防和早期诊断提供了有用信息。
