Zgutka Katarzyna, Tkacz Marta, Grabowska Marta, Mikołajek-Bedner Wioletta, Tarnowski Maciej
Department of Physiology in Health Sciences, Faculty of Health Sciences, Pomeranian Medical University, 70-210 Szczecin, Poland.
Department of Histology and Developmental Biology, Faculty of Health Sciences, Pomeranian Medical University, 71-210 Szczecin, Poland.
Pharmaceuticals (Basel). 2025 Jan 1;18(1):41. doi: 10.3390/ph18010041.
Gestational diabetes mellitus (GDM) imposes serious short- and long-term health problems for the mother and her child. An effective therapeutic that can reduce the incidence of GDM and improve long-term outcomes is a major research priority and is very important for public health. Unfortunately, despite numerous studies, the molecular mechanisms underlying GDM are not fully defined and require further study. Chronic low-grade inflammation, oxidative stress, and insulin resistance are central features of pregnancies complicated by GDM. There is evidence of the involvement of sirtuins, which are NAD+-dependent histone deacetylases, in energy metabolism and inflammation. Taking these facts into consideration, the role of sirtuins in the pathomechanism of GDM will be discussed.
妊娠期糖尿病（GDM）会给母亲及其孩子带来严重的短期和长期健康问题。一种能够降低GDM发病率并改善长期预后的有效治疗方法是一项重要的研究重点，对公共卫生非常重要。不幸的是，尽管进行了大量研究，GDM潜在的分子机制仍未完全明确，需要进一步研究。慢性低度炎症、氧化应激和胰岛素抵抗是并发GDM的妊娠的主要特征。有证据表明，作为NAD+依赖的组蛋白脱乙酰酶的沉默调节蛋白参与了能量代谢和炎症过程。考虑到这些事实，将讨论沉默调节蛋白在GDM发病机制中的作用。
